The daily alternation between sleep and wakefulness is one of the most dominant features
of our lives and is a manifestation of the intrinsic 24 h rhythmicity underlying almost every …

A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …

Sleep disturbances and circadian rhythm dysfunction have been widely demonstrated in
patients with bipolar disorder (BD). Irregularity of the sleep–wake rhythm, eveningness …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Background Sleep disturbances are prevalent in severe mental disorders but their type and
frequency across diagnostic categories has not been investigated in large scale studies …

The worldwide prevalence of sleep disorders is approximately 50%, with an even higher
occurrence in a psychiatric population. Bipolar disorder (BD) is a severe mental illness …

Objective: Disruptions in biological rhythms and sleep are a core aspect of mood disorders,
with sleep and rhythm changes frequently occurring prior to and during mood episodes …

Research in developmental psychopathology and clinical staging models has increasingly
sought to identify trans-diagnostic biomarkers or neurocognitive deficits that may play a role …

Altered behavioral rhythms are a fundamental diagnostic feature of mood disorders. Patients
report worse subjective sleep and objective measures confirm this, implicating a role for …

Background Bipolar disorder (BD) is a chronic relapsing-remitting psychiatric disorder.
Sleep and circadian rhythm disturbances persist during acute mood episodes of the disorder …