Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

HLA-DR molecules bind microbial peptides in an endosomal compartment and present
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …

Highlights•Two recent crystal structures show how DM interacts with MHCII proteins.•Studies
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …

Hyperglycemia and hyperlipidemia are often observed in individuals with type II diabetes
(T2D) and related mouse models. One dysmetabolic biochemical consequence is the non …

Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …

Studies have suggested that MHC class I (MHC I) molecules fluctuate rapidly between
numerous conformational states and these motions support peptide sampling. To date, MHC …

Conspectus Proteins are dynamic molecules that exhibit conformational flexibility to function
properly. Well-known examples of this are allosteric regulation of protein activity and ligand …

Antigen presentation is a cellular process that involves a number of steps, beginning with
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …

Recombinant αβ T cell receptors, expressed on T cell membranes, recognize short peptides
presented at the cell surface in complex with MHC molecules. There are two main subsets of …