Major histocompatibility complex (MHC) class I and MHC class II proteins: conformational plasticity in antigen presentation
M Wieczorek, ET Abualrous, J Sticht… - Frontiers in …, 2017 - frontiersin.org
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …
Class II MHC antigen processing in immune tolerance and inflammation
MM Jurewicz, LJ Stern - Immunogenetics, 2019 - Springer
Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …
[HTML][HTML] Crystal structure of the HLA-DM–HLA-DR1 complex defines mechanisms for rapid peptide selection
HLA-DR molecules bind microbial peptides in an endosomal compartment and present
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …
[HTML][HTML] HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation
ED Mellins, LJ Stern - Current opinion in immunology, 2014 - Elsevier
Highlights•Two recent crystal structures show how DM interacts with MHCII proteins.•Studies
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …
Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery
Hyperglycemia and hyperlipidemia are often observed in individuals with type II diabetes
(T2D) and related mouse models. One dysmetabolic biochemical consequence is the non …
(T2D) and related mouse models. One dysmetabolic biochemical consequence is the non …
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism
AI Guce, SE Mortimer, T Yoon, CA Painter… - Nature structural & …, 2013 - nature.com
Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …
Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing
L Li, X Peng, M Batliwala, M Bouvier - Nature Communications, 2023 - nature.com
Studies have suggested that MHC class I (MHC I) molecules fluctuate rapidly between
numerous conformational states and these motions support peptide sampling. To date, MHC …
numerous conformational states and these motions support peptide sampling. To date, MHC …
Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling
KD Rand, M Zehl, TJD Jørgensen - Accounts of chemical …, 2014 - ACS Publications
Conspectus Proteins are dynamic molecules that exhibit conformational flexibility to function
properly. Well-known examples of this are allosteric regulation of protein activity and ligand …
properly. Well-known examples of this are allosteric regulation of protein activity and ligand …
The role of molecular flexibility in antigen presentation and T cell receptor-mediated signaling
K Natarajan, J Jiang, NA May, MG Mage… - Frontiers in …, 2018 - frontiersin.org
Antigen presentation is a cellular process that involves a number of steps, beginning with
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …
Re-Directing CD4+ T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough
CJ Holland, DK Cole, A Godkin - Frontiers in immunology, 2013 - frontiersin.org
Recombinant αβ T cell receptors, expressed on T cell membranes, recognize short peptides
presented at the cell surface in complex with MHC molecules. There are two main subsets of …
presented at the cell surface in complex with MHC molecules. There are two main subsets of …