RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

Artificial intelligence (AI) and machine learning have significantly influenced many facets of
the healthcare sector. Advancement in technology has paved the way for analysis of big …

Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

Immunotherapies are yielding effective treatments for several previously untreatable
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …

RNA editing and splicing are the two major processes that dynamically regulate human
transcriptome diversity. Despite growing evidence of crosstalk between RNA editing …

Abstract Background N6‐methyladenosine (m6A), the most prevalent internal mRNA
modification in eukaryotes, is added by m6A methyltransferases, removed by m6A …

Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a
given gene, which can have distinct functions. In fact, splice isoforms can have opposing …

Uveal melanoma is the most common type of intraocular cancer with a low mean annual
incidence of 5-10 cases per million. Tumours are located in the choroid (90%), ciliary body …

Background Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by
catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is …

Alternative splicing (AS) is a critical post-transcriptional regulatory mechanism used by more
than 95% of transcribed human genes and responsible for structural transcript variation and …