Aspects of the development of mass spectrometry over the past three decades are briefly
reviewed and growth points in the subject are identified. Molecular imaging by mass …

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) using buckminsterfullerene
(C60) as the primary ion source has the ability to generate chemical images of surfaces with …

Atmospheric pressure imaging mass spectrometry is a rapidly expanding field that offers
advantages in the ability to study biological systems in their native condition, simplified …

Imaging mass spectrometry has emerged as a powerful technique based on time-of-flight
secondary-ion mass spectrometry (TOF-SIMS)[1] and matrix-assisted laser …

Time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS) using liquid metal ion guns
(LMIGs) is now sensitive enough to produce molecular‐ion images directly from biological …

Surface metallization by plasma coating enhances desorption/ionization of membrane
components such as lipids and sterols in imaging time-of-flight secondary ion mass …

Highlights•IMS improves analytical performance of MS imaging of biological tissue
samples.•Improvements in specificity and imaging accuracy are achieved for small …

A fast and simple, solvent-free matrix deposition protocol was developed for positive
ionization mode phospholipid analysis in tissues. Finely ground 2, 5-dihydroxybenzoic acid …

This concise tutorial review provides a description of the current state of the art in the
application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field …

Lipids, serving as the structural components of cellular membranes, energy storage, and
signaling molecules, play the essential and multiple roles in biological functions of …