In principle mass spectral imaging has enormous potential for discovery applications in
biology. The chemical specificity of mass spectrometry combined with spatial analysis …

Desorption electrospray ionization (DESI), a relatively new ambient ionization technique
used in mass spectrometry (MS), allows for the direct analysis of samples such as thin tissue …

One of the hallmarks of atherosclerosis is the accumulation of lipoproteins within the wall of
blood vessels. The lipid composition can vary among atheroma, even within a single …

Molecular events involved in successful embryo implantation are not well understood. In this
study, we used MALDI imaging mass spectrometry (IMS) technologies to characterize the …

Sphingolipids containing acyl residues that are hydroxylated at C-2 are found in most, if not
all, eukaryotes and certain bacteria. 2-hydroxylated sphingolipids are present in many …

Despite being a critical molecule in the brain, mass spectrometry imaging (MSI) of
cholesterol has been under-reported compared to other lipids due to the difficulty in ionizing …

Sphingolipids comprise a highly diverse and complex class of molecules that serve as both
structural components of cellular membranes and signaling molecules capable of eliciting …

Time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging is an analytical
technique rapidly expanding in use in biological studies. This technique is based on high …

Mass spectrometry imaging (MSI) has been extensively used for determining spatial
distributions of molecules in biological samples, and there is increasing interest in using MSI …

A buckminsterfullerene ion source is employed to characterize peptide-doped trehalose thin
films. The experiments are designed to utilize the unique sputtering properties of cluster ion …