Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) …

S Solé-Domènech, P Sjövall, V Vukojević… - Acta …, 2013 - Springer
The spatial distributions of lipids, amyloid-beta deposits, markers of neurons and glial cells
were imaged, at submicrometer lateral resolution, in brain structures of a mouse model of …

Why don't biologists use SIMS?: A critical evaluation of imaging MS

RMA Heeren, LA McDonnell, E Amstalden… - Applied Surface …, 2006 - Elsevier
Secondary ion mass spectrometry is commonly used to study many different types of
complex surfaces. Yet, compared with MALDI and ESI–MS, SIMS has not made a significant …

Secondary ion mass spectrometry

NP Lockyer, S Aoyagi, JS Fletcher, IS Gilmore… - Nature Reviews …, 2024 - nature.com
Secondary ion mass spectrometry (SIMS) is a technique for chemical analysis and imaging
of solid materials, with applications in many areas of science and technology. It involves …

Time‐of‐flight secondary ion mass spectrometry imaging in cultural heritage: A focus on old paintings

C Bouvier, S Van Nuffel, P Walter… - Journal of Mass …, 2022 - Wiley Online Library
Time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS) imaging is a surface analysis
technique that identifies and spatially resolves the chemical composition of a sample with a …

Cluster TOF‐SIMS imaging as a tool for micrometric histology of lipids in tissue

C Bich, D Touboul, A Brunelle - Mass spectrometry reviews, 2014 - Wiley Online Library
Recent developments in instrumentation, ion beams or analyzers, for cluster time‐of‐flight
secondary ion mass spectrometry (TOF‐SIMS) imaging are described here. The methods …

Depth Profiling Brain Tissue Sections with a 40 keV C60+ Primary Ion Beam

EA Jones, NP Lockyer, JC Vickerman - Analytical Chemistry, 2008 - ACS Publications
In this paper, the effect of prolonged C60+ primary ion bombardment on the chemical
information available from a section of rat brain is discussed. Initial attempts demonstrate the …

Sulfatide species with various fatty acid chains in oligodendrocytes at different developmental stages determined by imaging mass spectrometry

Y Hirahara, T Wakabayashi, T Mori… - Journal of …, 2017 - Wiley Online Library
Abstract HSO 3‐3‐galactosylceramide (Sulfatide) species comprise the major
glycosphingolipid components of oligodendrocytes and myelin and play functional roles in …

Protein kinase assay on peptide-conjugated gold nanoparticles by using secondary-ion mass spectrometric imaging

YP Kim, E Oh, YH Oh, DW Moon… - Angewandte Chemie …, 2007 - dgist.elsevierpure.com
Abstract (Figure Presented) Spot the mass of peptides: A label-free protein kinase assay that
uses secondary-ion mass spectrometric imaging has been demonstrated with peptide …

Micrometric molecular histology of lipids by mass spectrometry imaging

D Touboul, O Laprévote, A Brunelle - Current opinion in chemical biology, 2011 - Elsevier
Time-Of-Flight Secondary Ion Mass Spectrometry is compared to other mass spectrometry
imaging techniques, and recent improvements of the experimental methods, driven by …

Suppression and enhancement of secondary ion formation due to the chemical environment in static-secondary ion mass spectrometry

EA Jones, NP Lockyer, J Kordys… - Journal of the American …, 2007 - Springer
Through analyzing mixtures of compounds of known gas-phase basicities, the importance of
this property on the secondary ions emitted from a surface under primary ion bombardment …