Background γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …

The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

Identification of mechanisms which increase deep sleep could lead to novel treatments
which promote the restorative effects of sleep. Here, we show that knockdown of the α3 …

The hippocampus is a primary area for contextual memory, known to process spatiotemporal
information within a specific episode. Long-term strengthening of glutamatergic transmission …

The lack of effective therapies for epileptic patients and the potentially harmful
consequences of untreated seizure incidents have made epileptic disorders in humans a …

The neurosteroids progesterone and allopregnanolone regulate numerous neuroprotective
functions in neural tissues including inhibition of epileptic seizures and cell death. Many of …

Traumatic brain injury is a highly prevalent medical condition for which no medications
specific for the prophylaxis or treatment of the condition as a whole exist. The spectrum of …

Ion channels have been characterized as promising drug targets for treatment of numerous
human diseases. Functions of ion channels can be fine-tuned by allosteric modulators …

Background Epilepsy is a chronic neurological disorder that affects approximately 50–70
million people worldwide. Epilepsy has a significant economic and social burden on patients …