2023 ESC Guidelines for the management of endocarditis: Developed by the task force on the management of endocarditis of the European Society of Cardiology …

V Delgado, N Ajmone Marsan, S de Waha… - European heart …, 2023 - academic.oup.com
• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

X Li, S Wei, S Niu, X Ma, H Li, M Jing, Y Zhao - Computers in biology and …, 2022 - Elsevier
Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

[HTML][HTML] 2023 update on sepsis and septic shock in adult patients: management in the emergency department

M Guarino, B Perna, AE Cesaro, M Maritati… - Journal of clinical …, 2023 - mdpi.com
Background: Sepsis/septic shock is a life-threatening and time-dependent condition that
requires timely management to reduce mortality. This review aims to update physicians with …

Association of appropriate empirical antimicrobial therapy with in-hospital mortality in patients with bloodstream infections in the US

T Ohnuma, S Chihara, B Costin, MM Treggiari… - JAMA Network …, 2023 - jamanetwork.com
Importance Bloodstream infections (BSIs) are a major public health problem associated with
high morbidity. Little evidence exists regarding the epidemiology of BSIs and the use of …

[HTML][HTML] Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study

N Buetti, A Tabah, A Loiodice, S Ruckly, AT Aslan… - Critical Care, 2022 - Springer
Background The study aimed to describe the epidemiology and outcomes of hospital-
acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically …

[HTML][HTML] Treatment of critically ill patients with cefiderocol for infections caused by multidrug-resistant pathogens: review of the evidence

P Viale, CE Sandrock, P Ramirez, GM Rossolini… - Annals of intensive …, 2023 - Springer
Appropriate antibiotic treatment for critically ill patients with serious Gram-negative infections
in the intensive care unit is crucial to minimize morbidity and mortality. Several new …

[HTML][HTML] Recent advances in monoclonal antibody-based approaches in the management of bacterial sepsis

K Kharga, L Kumar, SKS Patel - Biomedicines, 2023 - mdpi.com
Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …

Simultaneous detection of C-reactive protein and lipopolysaccharide based on a dual-channel electrochemical biosensor for rapid Gram-typing of bacterial sepsis

TC Lu, YJ Yang, Y Zhong, QZ Qiu, ZH Chen… - Biosensors and …, 2024 - Elsevier
Sepsis is a life-threatening multi-organ failure syndrome, with bacterial infections being the
most common cause. Rapid Gram-typing is imperative to assist in antibiotic intervention. C …

Broad-Spectrum Clearance of Lipopolysaccharides from Blood Based on a Hemocompatible Dihistidine Polymer

J Chen, Z Shi, X Yang, X Zhang, D Wang… - … Applied Materials & …, 2023 - ACS Publications
Blood infection can release toxic bacterial lipopolysaccharides (LPSs) into bloodstream,
trigger a series of inflammatory reactions, and eventually lead to multiple organ dysfunction …

[HTML][HTML] Rapid and visual identification of β-lactamase subtypes for precision antibiotic therapy

W Li, J Li, H Xu, H Gao, D Liu - Nature Communications, 2024 - nature.com
The abuse of antibiotics urgently requires rapid identification of drug-resistant bacteria at the
point of care (POC). Here we report a visual paper sensor that allows rapid (0.25-3 h) …