Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain
a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high …

Proteases are involved in a broad range of physiological processes, including host invasion
by fungal pathogens, and enzymatic inhibition is a key molecular mechanism controlling …

Invasive fungal infections (IFIs) are emerging as a serious threat to public health and are
associated with high incidence and mortality. IFIs also represent a frequent complication in …

Cryptococcus neoformans, an opportunistic fungal pathogen ubiquitously present in the
environment, causes cryptococcal meningitis (CM) mainly in immunocompromised patients …

Cryptococcus neoformans is a globally important fungal pathogen, primarily inflicting
disease on immunocompromised individuals. The widespread use of antifungal agents in …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss and cognitive impairment due in part to a severe loss of cholinergic neurons in …

Cryptococcus neoformans is a human fungal pathogen responsible for fatal infections,
especially in patients with a depressed immune system. Overexposure to antifungal drugs …

Generally, Cryptococcus initially infects the respiratory tract, but can spread, eventually
crossing the blood-brain barrier (BBB) and causing meningitis or meningoencephalitis …

Background: The field of medicine and synthetic drug development have advanced rapidly
over the past few decades. However, research on alternative medicine, such as …

Cryptococcal meningoencephalitis, a disease with poor patient outcomes, remains the most
prevalent invasive fungal infection worldwide, accounting for approximately 180,000 deaths …