Progranulin (PGRN) is a widely expressed secreted protein that is linked to inflammation. In
humans, PGRN haploinsufficiency is a major inherited cause of frontotemporal dementia …

Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of disorders
characterized by disturbances of behavior and personality and different types of language …

The first reports of disorders that in terms of cognitive and behavioral symptoms resemble
frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic …

The TAR DNA-binding protein 43 (TDP-43) has been identified as the major disease protein
in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin …

Amyotrophic lateral sclerosis (ALS) is a degenerative disorder that is characterized by loss
of motor neurons and shows clinical, pathological, and genetic overlap with frontotemporal …

TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and
familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions …

Recently, mutations in the progranulin (PGRN) gene were found to cause familial and
apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in …

The growth factor progranulin (PGRN) regulates cell division, survival, and migration. PGRN
is an extracellular glycoprotein bearing multiple copies of the cysteine‐rich granulin motif …

The balance between synthesis and degradation is crucial to maintain cellular homeostasis
and different mechanisms are known to keep this balance. In this review, we will provide a …

Haploinsufficiency of the progranulin (PGRN) gene (GRN) causes familial frontotemporal
lobar degeneration (FTLD) and modulates an innate immune response in humans and in …