Through an international consortium, we have collected 37 tau-and TAR DNA-binding
protein 43 (TDP-43)-negative frontotemporal lobar degeneration (FTLD) cases, and present …

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is a fatal
neurodegenerative disease with no available treatments. Mutations in the progranulin gene …

Loss-of-function mutations in progranulin, a lysosomal glycoprotein, cause
neurodegenerative disease. Progranulin haploinsufficiency causes frontotemporal dementia …

Progressive supranuclear palsy (PSP) is an atypical Parkinsonian disorder associated with
progressive axial rigidity, vertical gaze palsy, dysarthria and dysphagia …

TMEM106B, encoding a lysosome membrane protein, has been recently associated with
brain aging, hypomyelinating leukodystrophy and multiple neurodegenerative diseases …

Loss-of-function mutations in progranulin (GRN) cause ubiquitin-and TAR DNA-binding
protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive …

The term frontotemporal dementia (FTD) describes a clinically, genetically and
pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present …

Frontotemporal lobar degeneration (FTLD) comprises a highly heterogeneous group of
disorders clinically associated with behavioral and personality changes, language …

Background: Mutations in the progranulin gene (PGRN) were identified as the causal
mechanism underlying frontotemporal lobar degeneration (FTLD). Most of these mutations …

Loss-of-function mutations in the progranulin gene are a common cause of familial
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …