Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

Dendritic spines are small protrusive structures on dendritic surfaces, and function as
postsynaptic compartments for excitatory synapses. Plasticity of spine structure is associated …

Activity-dependent plasticity of synaptic structure and function plays an essential role in
neuronal development and in cognitive functions including learning and memory. The …

The formation of correct synaptic structures and neuronal connections is paramount for
normal brain development and a functioning adult brain. The integrin family of cell adhesion …

Genetic studies of autism spectrum disorder (ASD) have revealed multigene variations that
converge on synaptic dysfunction. DOCK4, a gene at 7q31. 1 that encodes the Rac1 …

Autism spectrum disorder is a neurodevelopmental condition characterized by impaired
social communication and repetitive behaviors. Changes in the number of specific cell types …

Learning and memory require structural and functional modifications of synaptic
connections, and synaptic deficits are believed to underlie many brain disorders. The LIM …

We recently identified an autism spectrum disorder/intellectual disability (ASD/ID)-related de
novo mutation hotspot in the Rac1-activating GEF1 domain of the protein Trio. Trio is a Rho …

Genetic research in Autism Spectrum Disorder (ASD) has progressed tremendously in
recent decades. Dozens of genetic loci and hundreds of alterations in the genetic sequence …

The volume and the electric strength of an excitatory synapse is near linearly correlated with
the area of its postsynaptic density (PSD). Extensive research in the past has revealed that …