The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

The circadian clock is a timekeeping system for numerous biological rhythms that contribute
to the regulation of numerous homeostatic processes in humans. Disruption of circadian …

Background While epidemiological studies have found correlations between light at night
(LAN) and health effects, none has so far investigated the impacts of LAN on population …

Colorectal cancer (CRC) is a common gastrointestinal malignancy with higher incidence
and mortality rates in men compared to women, potentially due to the effects of estrogen …

The molecular machinery of the circadian clock regulates the expression of many genes and
processes in the organism, allowing the adaptation of cellular activities to the daily light-dark …

Circadian medicine, the study of the effects of time on health and disease has seen an
uprising in recent years as a means to enhance health and performance, and optimize …

An increasingly older population is one of the major social and medical challenges we
currently face. Between 2010 and 2050, it is estimated that the proportion of adults over 65 …

O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a dynamic post-translational
modification that regulates thousands of proteins and almost all cellular processes. Aberrant …

CYP2A5, an enzyme responsible for metabolism of diverse drugs, displays circadian
rhythms in its expression and activity. However, the underlying mechanisms are not fully …

The Aryl hydrocarbon receptor (AhR) is a xenobiotic and endobiotic receptor, which
regulates many cellular processes from contaminant metabolism to immunomodulation …