The crAss-like phage group: how metagenomics reshaped the human virome
EV Koonin, N Yutin - Trends in Microbiology, 2020 - cell.com
Metagenomics is currently the primary means for identifying new viruses. One of the most
impactful metagenomic discoveries is that of crAssphage, the most abundant human …
impactful metagenomic discoveries is that of crAssphage, the most abundant human …
Discovering biological conflict systems through genome analysis: evolutionary principles and biochemical novelty
Biological replicators, from genes within a genome to whole organisms, are locked in
conflicts. Comparative genomics has revealed a staggering diversity of molecular …
conflicts. Comparative genomics has revealed a staggering diversity of molecular …
Discovery of an expansive bacteriophage family that includes the most abundant viruses from the human gut
N Yutin, KS Makarova, AB Gussow, M Krupovic… - Nature …, 2018 - nature.com
Metagenomic sequence analysis is rapidly becoming the primary source of virus discovery,–
. A substantial majority of the currently available virus genomes come from metagenomics …
. A substantial majority of the currently available virus genomes come from metagenomics …
Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling
AM Burroughs, D Zhang, DE Schäffer… - Nucleic acids …, 2015 - academic.oup.com
Cyclic di-and linear oligo-nucleotide signals activate defenses against invasive nucleic
acids in animal immunity; however, their evolutionary antecedents are poorly understood …
acids in animal immunity; however, their evolutionary antecedents are poorly understood …
[HTML][HTML] Jumbo phages: a comparative genomic overview of core functions and adaptions for biological conflicts
Jumbo phages have attracted much attention by virtue of their extraordinary genome size
and unusual aspects of biology. By performing a comparative genomics analysis of 224 …
and unusual aspects of biology. By performing a comparative genomics analysis of 224 …
Origin and evolution of eukaryotic transcription factors
A de Mendoza, A Sebé-Pedrós - Current Opinion in Genetics & …, 2019 - Elsevier
Transcription factors (TFs) have a central role in genome regulation directing gene
transcription through binding specific DNA sequences. Eukaryotic genomes encode a large …
transcription through binding specific DNA sequences. Eukaryotic genomes encode a large …
[HTML][HTML] The replication machinery of LUCA: common origin of DNA replication and transcription
EV Koonin, M Krupovic, S Ishino, Y Ishino - BMC biology, 2020 - Springer
Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs)
are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The …
are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The …
[HTML][HTML] Multisubunit RNA polymerases of jumbo bacteriophages
ML Sokolova, I Misovetc, K V. Severinov - Viruses, 2020 - mdpi.com
Prokaryotic viruses with DNA genome longer than 200 kb are collectively referred to as
“jumbo phages”. Some representatives of this phylogenetically diverse group encode two …
“jumbo phages”. Some representatives of this phylogenetically diverse group encode two …
Basic mechanism of transcription by RNA polymerase II
V Svetlov, E Nudler - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2013 - Elsevier
RNA polymerase II-like enzymes carry out transcription of genomes in Eukaryota, Archaea,
and some viruses. They also exhibit fundamental similarity to RNA polymerases from …
and some viruses. They also exhibit fundamental similarity to RNA polymerases from …
Transposons to toxins: the provenance, architecture and diversification of a widespread class of eukaryotic effectors
Enzymatic effectors targeting nucleic acids, proteins and other cellular components are the
mainstay of conflicts across life forms. Using comparative genomics we identify a large class …
mainstay of conflicts across life forms. Using comparative genomics we identify a large class …