Reproduction involves a wide range of biological processes, including organ formation and
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …

Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it
controls the correct segregation of chromosomes during mitosis. Many studies have focused …

Over the past half-century, the world has witnessed a steep decline in fertility rates in
virtually every country on Earth. This universal decline in fertility is being driven by …

BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …

Peptidyl arginine deiminase 6 (PADI6) is a maternal factor that is vital for early embryonic
development. Deletion and mutations of its encoding gene in female mice or women lead to …

Chemically defined oocyte maturation media supplemented with FGF2, LIF, and IGF-1 (FLI
medium) enabled significantly improved oocyte quality in multiple farm animals, yet the …

Unexplained infertility affects about one-third of infertile couples and is defined as the failure
to identify the cause of infertility despite extensive evaluation of the male and female …

Two decades have passed since the discovery of phospholipase C zeta (PLCZ1) as the
sperm oocyte-activating factor. At present, there is a general consensus that PLCZ1 is …

Purpose Providing additional insights on the efficacy of human nuclear transfer (NT). Here,
and earlier, NT has been applied to minimize transmission risk of mitochondrial DNA …

Purpose This study aims to identify the genetic causes of 12 women with primary infertility
characterized by primarily oocyte maturation abnormality and consequent early embryonic …