Gastric cancer accounts for the majority cancer-related deaths worldwide. Although various
methods have considerably improved the screening, diagnosis, and treatment of gastric …

The antitumor activity of newly synthesised triazolophthalazines (L-45 analogues) 10–32
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …

The antitumor activity of newly synthesized 4-anilino-2-vinylquinazolines 8a-r was measured
comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated …

This review explains the effects of naproxen and the naproxen moiety in important biological
activities. Naproxen, 2-(6-methoxynaphthalen-2-yl) propionic acid, is one of the most utilized …

Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We
synthesised a series of hydrazones (compounds 4–24) incorporating a 4 …

Selective COX-2 inhibitors have been considered to be reliable alternatives to tNSAIDs, but
most of them were withdrawn from the market due to their risk of heart attack and stroke …

Drug repurposing is an emerging field in drug development that has provided many
successful drugs. In the current study, paracetamol, a known antipyretic and analgesic …

We evaluated the hCA (CA, EC 4.2. 1.1) inhibitory activity of novel 4-(2-(2-substituted-thio-4-
oxoquinazolin-3 (4H)-yl) ethyl) benzenesulfonamides (compounds 2–20) towards the …

The objective of this study was to synthesize seven novel thiourea derivatives of naproxen (8–
14), examine the anti-inflammatory activity of the newly synthesized compounds, investigate …

A group of novel maleimide-benzenesulfonamide derivatives 3a-d was designed and
synthesized for their evaluation as a potential anti-breast cancer agent. The structures of …