[HTML][HTML] Genetic variant of cyclooxygenase-2 in gastric cancer: More inflammation and susceptibility
XK Ji, SV Madhurapantula, G He, KY Wang… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Gastric cancer accounts for the majority cancer-related deaths worldwide. Although various
methods have considerably improved the screening, diagnosis, and treatment of gastric …
methods have considerably improved the screening, diagnosis, and treatment of gastric …
Design, synthesis, and antitumor activity of novel compounds based on 1, 2, 4-triazolophthalazine scaffold: apoptosis-inductive and PCAF-inhibitory effects
The antitumor activity of newly synthesised triazolophthalazines (L-45 analogues) 10–32
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies
The antitumor activity of newly synthesized 4-anilino-2-vinylquinazolines 8a-r was measured
comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated …
comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated …
Anticancer and antimicrobial activities of naproxen and naproxen derivatives
Mİ Han, ŞG Küçükgüzel - Mini reviews in medicinal chemistry, 2020 - ingentaconnect.com
This review explains the effects of naproxen and the naproxen moiety in important biological
activities. Naproxen, 2-(6-methoxynaphthalen-2-yl) propionic acid, is one of the most utilized …
activities. Naproxen, 2-(6-methoxynaphthalen-2-yl) propionic acid, is one of the most utilized …
Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a …
Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We
synthesised a series of hydrazones (compounds 4–24) incorporating a 4 …
synthesised a series of hydrazones (compounds 4–24) incorporating a 4 …
Synthesis and biological evaluation of resveratrol amide derivatives as selective COX-2 inhibitors
M Xin, H Wu, Y Du, S Liu, F Zhao, X Mou - Chemico-Biological Interactions, 2023 - Elsevier
Selective COX-2 inhibitors have been considered to be reliable alternatives to tNSAIDs, but
most of them were withdrawn from the market due to their risk of heart attack and stroke …
most of them were withdrawn from the market due to their risk of heart attack and stroke …
New paracetamol hybrids as anticancer and COX‐2 inhibitors: Synthesis, biological evaluation and docking studies
MM Alam, NI Alsenani, AA Abdelhamid… - Archiv der …, 2024 - Wiley Online Library
Drug repurposing is an emerging field in drug development that has provided many
successful drugs. In the current study, paracetamol, a known antipyretic and analgesic …
successful drugs. In the current study, paracetamol, a known antipyretic and analgesic …
S-substituted 2-mercaptoquinazolin-4 (3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors
We evaluated the hCA (CA, EC 4.2. 1.1) inhibitory activity of novel 4-(2-(2-substituted-thio-4-
oxoquinazolin-3 (4H)-yl) ethyl) benzenesulfonamides (compounds 2–20) towards the …
oxoquinazolin-3 (4H)-yl) ethyl) benzenesulfonamides (compounds 2–20) towards the …
Synthesis, characterization, and investigation of anti-inflammatory and cytotoxic activities of novel thiourea derivatives of naproxen
N Nedeljković, M Nikolić, P Čanović, M Zarić… - Pharmaceutics, 2023 - mdpi.com
The objective of this study was to synthesize seven novel thiourea derivatives of naproxen (8–
14), examine the anti-inflammatory activity of the newly synthesized compounds, investigate …
14), examine the anti-inflammatory activity of the newly synthesized compounds, investigate …
Design, cytotoxic effects on breast cancer cell line (MDA-MB 231), and molecular docking of some maleimide-benzenesulfonamide derivatives
A group of novel maleimide-benzenesulfonamide derivatives 3a-d was designed and
synthesized for their evaluation as a potential anti-breast cancer agent. The structures of …
synthesized for their evaluation as a potential anti-breast cancer agent. The structures of …