Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms

S Mei, H Ma, X Chen - Food and Chemical Toxicology, 2021 - Elsevier
Chronic inflammation is crucial for the pathological process of tumors due to increasing the
infiltration of cytokines, growth factors, and chemokines to the tumor microenvironment …

Therapeutic potential of mangiferin in cancer: Unveiling regulatory pathways, mechanisms of action, and bioavailability enhancements–An updated review

H Iqbal, M Inam‐Ur‐Raheem, S Munir… - Food Science & …, 2024 - Wiley Online Library
Mangiferin (MGF) is a phenolic compound, which is a major source of MGF is the mango
tree. MGF possesses some antioxidant, anti‐inflammatory, and cytoprotective properties …

Circular RNA PLCE1 promotes epithelial mesenchymal transformation, glycolysis in colorectal cancer and M2 polarization of tumor-associated macrophages

B Yi, KJ Dai, ZQ Yan, ZH Yin - Bioengineered, 2022 - Taylor & Francis
Plentiful studies have clarified that circular RNAs (circRNAs) are crucial in colorectal cancer
(CRC)'s occurrence and development, but its function has not been fully elucidated. The …

Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical …

S Fakhri, SZ Moradi, F Faraji, L Kooshki… - Cancer and Metastasis …, 2024 - Springer
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

[HTML][HTML] The role of circadian clocks in cancer: Mechanisms and clinical implications

H Liu, Y Liu, R Hai, W Liao, X Luo - Genes & Diseases, 2023 - Elsevier
Circadian rhythm refers to the inherent 24-h cycle oscillation of biochemical, physiological
and behavioral functions, which is almost universal in eukaryotes. At least 14 core clock …

STEAP4 knockdown inhibits the proliferation of prostate cancer cells by activating the cGMP-PKG pathway under lipopolysaccharide-induced inflammatory …

W Li, X Yin, Y Yan, C Liu, G Li - International Immunopharmacology, 2021 - Elsevier
Six-transmembrane epithelial antigen of prostate 4 (STEAP4) is involved in the development
of human cancers. However, the role of STEAP4 in prostate cancer remains largely …

Transferrin-modified mangiferin-loaded SLNs: preparation, characterization, and application in A549 lung cancer cell

Q Zhou, K Hou, Z Fu - Drug design, development and therapy, 2023 - Taylor & Francis
Introduction Mangiferin is a plant antitumor compound with poor water solubility and low
bioavailability. In this study, transferrin-modified mangiferin-loaded solid lipid nanoparticles …

1‐Monopalmitin promotes lung cancer cells apoptosis through PI3K/A kt pathway in vitro

L Niu, W Li, X Chen, X Su, J Dong, Q Liao… - Environmental …, 2023 - Wiley Online Library
Lung cancer is the leading cause of cancer‐related death worldwide and non‐small cell
lung cancer (NSCLC) represents 85%. Mougeotia nummuloides and Spirulina major have …

EPN3 plays oncogenic role in non‐small cell lung cancer by activating the JAK1/2‐STAT3 pathway

J Meng, C Zhang, N Zhu, C Zhang, M Liu… - Environmental …, 2023 - Wiley Online Library
The effect of Epsin 3 (EPN3) on non‐small cell lung cancer (NSCLC) has not yet been
clearly elucidated. This study identified the exact function of EPN3 on NSCLC progression …

[HTML][HTML] PER1 is a prognostic biomarker and correlated with immune infiltrates in ovarian cancer

M Chen, L Zhang, X Liu, Z Ma, L Lv - Frontiers in Genetics, 2021 - frontiersin.org
Background: Period circadian protein homolog 1 (PER1) is an important component of the
biorhythm molecular oscillation system and plays an important part in the development and …