mRNA capping: biological functions and applications
The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …
of research have established that the m7G cap serves as a unique molecular module that …
The nonsense-mediated decay RNA surveillance pathway
YF Chang, JS Imam, MF Wilkinson - Annu. Rev. Biochem., 2007 - annualreviews.org
Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively
degrades mRNAs harboring premature termination (nonsense) codons. If translated, these …
degrades mRNAs harboring premature termination (nonsense) codons. If translated, these …
Proteome survey reveals modularity of the yeast cell machinery
Protein complexes are key molecular entities that integrate multiple gene products to
perform cellular functions. Here we report the first genome-wide screen for complexes in an …
perform cellular functions. Here we report the first genome-wide screen for complexes in an …
[HTML][HTML] The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions
Eukaryotic mRNAs exist in vivo as ribonucleoprotein particles (mRNPs). The protein
components of mRNPs have important functions in mRNA metabolism, including effects on …
components of mRNPs have important functions in mRNA metabolism, including effects on …
Novel “anti-reverse” cap analogs with superior translational properties
J Jemielity, T Fowler, J Zuberek, J Stepinski… - Rna, 2003 - rnajournal.cshlp.org
Synthetic analogs of the 5′-terminal caps of eukaryotic mRNAs and snRNAs are used in
elucidating such physiological processes as mRNA translation, pre-mRNA splicing …
elucidating such physiological processes as mRNA translation, pre-mRNA splicing …
The cap-to-tail guide to mRNA turnover
CJ Wilusz, M Wormington, SW Peltz - Nature reviews Molecular cell …, 2001 - nature.com
The levels of cellular messenger RNA transcripts can be regulated by controlling the rate at
which the mRNA decays. Because decay rates affect the expression of specific genes, they …
which the mRNA decays. Because decay rates affect the expression of specific genes, they …
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20
Y Ishigaki, X Li, G Serin, LE Maquat - Cell, 2001 - cell.com
Nonsense-mediated decay (NMD) eliminates mRNAs that prematurely terminate translation.
We used antibody to the nuclear cap binding protein CBP80 or its cytoplasmic counterpart …
We used antibody to the nuclear cap binding protein CBP80 or its cytoplasmic counterpart …
The power of the 3′ UTR: translational control and development
S Kuersten, EB Goodwin - Nature Reviews Genetics, 2003 - nature.com
Many crucial decisions, such as the location and timing of cell division, cell-fate
determination, and embryonic axes establishment, are made in the early embryo, a time in …
determination, and embryonic axes establishment, are made in the early embryo, a time in …
Cap-binding complex (CBC)
T Gonatopoulos-Pournatzis, VH Cowling - Biochemical Journal, 2014 - portlandpress.com
The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene
expression. Protein complexes recruited to 7mG mediate key processing events throughout …
expression. Protein complexes recruited to 7mG mediate key processing events throughout …
Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae
In this review, we provide an overview of protein synthesis in the yeast Saccharomyces
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …