[HTML][HTML] Classic vs. C–H functionalization strategies in the synthesis of APIs: a sustainability comparison
The landscape of organic synthesis has changed in the last two decades, especially in
areas such as pharmaceutical synthesis and large-scale industrial synthesis. The progress …
areas such as pharmaceutical synthesis and large-scale industrial synthesis. The progress …
Continuous integrated manufacturing for biopharmaceuticals: A new paradigm or an empty promise?
Continuous integrated bioprocessing has elicited considerable interest from the biopharma
industry for the many purported benefits it promises. Today many major biopharma …
industry for the many purported benefits it promises. Today many major biopharma …
Advanced real‐time process analytics for multistep synthesis in continuous flow
P Sagmeister, R Lebl, I Castillo, J Rehrl… - Angewandte Chemie …, 2021 - Wiley Online Library
In multistep continuous flow chemistry, studying complex reaction mixtures in real time is a
significant challenge, but provides an opportunity to enhance reaction understanding and …
significant challenge, but provides an opportunity to enhance reaction understanding and …
Integrated continuous pharmaceutical technologies—a review
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …
and development of new active compounds; meanwhile, the structure of the production …
[HTML][HTML] Importance of Green and Sustainable Chemistry in the Chemical Industry: A joint virtual issue between ACS Sustainable Chemistry & Engineering and …
J Colberg, K Kuok (Mimi) Hii… - … Process Research & …, 2022 - ACS Publications
Chemistry contributes to virtually every aspect of modern life, from the production of fuels,
food, and clean drinking water to medicines, cleaners, personal care, as well as a host of …
food, and clean drinking water to medicines, cleaners, personal care, as well as a host of …
[HTML][HTML] Reactor design and selection for effective continuous manufacturing of pharmaceuticals
C Hu - Journal of Flow Chemistry, 2021 - Springer
Pharmaceutical production remains one of the last industries that predominantly uses batch
processes, which are inefficient and can cause drug shortages due to the long lead times or …
processes, which are inefficient and can cause drug shortages due to the long lead times or …
Combining computational fluid dynamics, photon fate simulation and machine learning to optimize continuous-flow photocatalytic systems
Photoredox catalysis is a well-established area with great potential for industrial
applications. The need for an optimum process with less waste generation and economic …
applications. The need for an optimum process with less waste generation and economic …
Continuous manufacturing of active pharmaceutical ingredients: current trends and perspectives
A Hyer, D Gregory, K Kay, Q Le… - Advanced Synthesis …, 2024 - Wiley Online Library
The pharmaceutical industry has traditionally employed batch processing as a means of
synthesizing active pharmaceutical ingredients (APIs) on a commercial scale. Batch …
synthesizing active pharmaceutical ingredients (APIs) on a commercial scale. Batch …
[HTML][HTML] A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries
G Gambacorta, JS Sharley… - Beilstein journal of …, 2021 - beilstein-journals.org
Due to their intrinsic physical properties, which includes being able to perform as volatile
liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal …
liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal …
Heterogeneous crystallization as a process intensification technology in an integrated continuous manufacturing process for pharmaceuticals
CJ Testa, K Shvedova, C Hu, W Wu… - … Process Research & …, 2021 - ACS Publications
Continuous heterogeneous crystallization processes in mixed-suspension mixed-product
removal (MSMPR) crystallizers of different configurations (eg, single-stage cooling …
removal (MSMPR) crystallizers of different configurations (eg, single-stage cooling …