Revisiting the virulence hallmarks of Pseudomonas aeruginosa: a chronicle through the perspective of quorum sensing
Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …
Drug repurposing for antimicrobial discovery
Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …
Quorum-sensing systems as targets for antivirulence therapy
T Defoirdt - Trends in microbiology, 2018 - cell.com
The development of novel therapies to control diseases caused by antibiotic-resistant
pathogens is one of the major challenges we are currently facing. Many important plant …
pathogens is one of the major challenges we are currently facing. Many important plant …
Drug repurposing for the treatment of bacterial and fungal infections
A Miró-Canturri, R Ayerbe-Algaba… - Frontiers in microbiology, 2019 - frontiersin.org
Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …
demands effective solutions; the situation is deemed a global priority by the World Health …
Pseudomonas aeruginosa adapts its iron uptake strategies in function of the type of infections
P Cornelis, J Dingemans - Frontiers in cellular and infection …, 2013 - frontiersin.org
Pseudomonas aeruginosa is a Gram-negative γ-Proteobacterium which is known for its
capacity to colonize various niches, including some invertebrate and vertebrate hosts …
capacity to colonize various niches, including some invertebrate and vertebrate hosts …
Nucleotide biosynthesis: the base of bacterial pathogenesis
Most free-living organisms require the synthesis and/or acquisition of purines and
pyrimidines, which form the basis of nucleotides, to survive. In most bacteria, the nucleotides …
pyrimidines, which form the basis of nucleotides, to survive. In most bacteria, the nucleotides …
Role of iron uptake systems in Pseudomonas aeruginosa virulence and airway infection
F Minandri, F Imperi, E Frangipani, C Bonchi… - Infection and …, 2016 - Am Soc Microbiol
Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and chronic
lung infections in cystic fibrosis patients. Iron is essential for bacterial growth, and P …
lung infections in cystic fibrosis patients. Iron is essential for bacterial growth, and P …
Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa
C Rezzoagli, M Archetti, I Mignot, M Baumgartner… - PLoS …, 2020 - journals.plos.org
Antibiotics are losing efficacy due to the rapid evolution and spread of resistance.
Treatments targeting bacterial virulence factors have been considered as alternatives …
Treatments targeting bacterial virulence factors have been considered as alternatives …
Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response
Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a
variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is …
variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is …
Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa
The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both
in vitro and in animal models of infection and is considered an ideal target for the …
in vitro and in animal models of infection and is considered an ideal target for the …