Manipulation of Human Ovarian Function: Physiological Concepts and Clinical
Consequences* | Endocrine Reviews | Oxford Academic Skip to Main Content …

As many as 80% of reproductive-aged women experience physical changes associated with
menstruation, and 20% to 40% experience menstrual-cycle-related symptoms. Decades of …

Objectives The aim of the study was to evaluate the efficacy of different dosages of estetrol
(E 4) combined with one of two progestins in suppressing the pituitary–ovarian axis and …

Steroid drugs with contraceptive properties have been available in the clinical setting for
over four decades and are still subject to improvement. Estrogens, progestins and anti …

The major developments in combined oral contraceptives (COCs) have been a reduction in
the total dose of both the oestrogen and progestogen administered per cycle and the …

Introduction: Following a historical overview, the ovulation-inhibiting effect of various orally
administered estrogen-progestin combinations (combined oral contraceptives [COCs]) are …

The newer progestogens gestodene, desogestrel and norgestimate were developed in an
attempt to produce agents with more selective progestational activity that would improve …

Objective: To examine the effect of age on the response to treatment with a combined oral
contraceptive. Design: Prospective, controlled clinical study. Setting: Reproductive medicine …

Objective In women who use oral contraceptives with low estrogen doses, a quiescent
endometrium is frequently produced. Further reduction of the estrogen dose would not be …

An open label, non-comparative study was carried out in 22 women over a total of five
cycles. After an untreated cycle, oral administration of 20 μg ethinyl estradiol (EE) with 50 μg …