From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
The human body hosts an enormous abundance and diversity of microbes, which perform a
range of essential and beneficial functions. Our appreciation of the importance of these …
range of essential and beneficial functions. Our appreciation of the importance of these …
Weight loss is a critical factor to reduce inflammation
VE Bianchi - Clinical nutrition ESPEN, 2018 - Elsevier
Background Chronic inflammation is a process sustained by the augmentation of circulating
cytokines level and C-reactive protein (CRP). Adipocytes and adipose tissue infiltration with …
cytokines level and C-reactive protein (CRP). Adipocytes and adipose tissue infiltration with …
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
JM Valentine, M Ahmadian, O Keinan… - The Journal of …, 2022 - Am Soc Clin Investig
The dysregulation of energy homeostasis in obesity involves multihormone resistance.
Although leptin and insulin resistance have been well characterized, catecholamine …
Although leptin and insulin resistance have been well characterized, catecholamine …
Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet
PE Bunney, AN Zink, AA Holm, CJ Billington… - Physiology & …, 2017 - Elsevier
Overweight and obesity result from an imbalance between caloric intake and energy
expenditure, including expenditure from spontaneous physical activity (SPA). Changes in …
expenditure, including expenditure from spontaneous physical activity (SPA). Changes in …
[HTML][HTML] TBK1 at the crossroads of inflammation and energy homeostasis in adipose tissue
The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-
inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we …
inflammatory cytokines, but its role in controlling metabolism remains unclear. Here, we …
Wnt/β-catenin signaling and obesity
N Chen, J Wang - Frontiers in physiology, 2018 - frontiersin.org
Obesity has become epidemic worldwide, which triggers several obesity-associated
complications. Obesity is characterized by excess fat storage mainly in the visceral white …
complications. Obesity is characterized by excess fat storage mainly in the visceral white …
Fine particulate matter induces adipose tissue expansion and weight gain: Pathophysiology
L Della Guardia, L Wang - Obesity Reviews, 2023 - Wiley Online Library
Dysregulations in energy balance represent a major driver of obesity. Recent evidence
suggests that environmental factors also play a pivotal role in inducing weight gain. Chronic …
suggests that environmental factors also play a pivotal role in inducing weight gain. Chronic …
[HTML][HTML] Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity
Objective/methods DNA methylation plays an important role in obesity and related metabolic
complications. We examined genome-wide DNA promoter methylation along with mRNA …
complications. We examined genome-wide DNA promoter methylation along with mRNA …
Sex differences in response to short-term high fat diet in mice
Background Consumption of high-fat diet (HF) leads to hyperphagia and increased body
weight in male rodents. Female rodents are relatively resistant to hyperphagia and weight …
weight in male rodents. Female rodents are relatively resistant to hyperphagia and weight …
Brain serotonin in high-fat diet-induced weight gain, anxiety and spatial memory in rats
Objectives: Effects of high-fat diet (HFD) consumption on body weight gain and its
consequences on anxiety, learning and memory, and serotonin metabolism (5 …
consequences on anxiety, learning and memory, and serotonin metabolism (5 …