The rising prevalence of obesity and metabolic disorders worldwide highlights the urgent
need to find new long-term and clinically meaningful weight-loss therapies. Here, we …

Circular RNAs (circRNAs) are emerging as novel regulators in the biological development of
various diseases, but their expression profiles, functions and mechanisms in silicosis and …

Metabolic dysfunction–associated steatotic liver disease (MASLD), formerly known as non-
alcoholic fatty liver disease (NAFLD), has become a major cause of chronic liver disease …

Obesity-associated metabolic inflammation drives the development of insulin resistance and
type 2 diabetes, notably through modulating innate and adaptive immune cells in metabolic …

Portal tracts are key intrahepatic structures where leukocytes accumulate during immune
responses. They contain the blood inflow, which includes portal blood from the gut, and …

Rational: The complex vascular architecture and diverse immune cells of the liver are critical
for maintaining liver homeostasis. However, quantification of the network of liver vasculature …

Liver allograft recipients are more likely to develop transplantation tolerance than those that
receive other types of organ graft. Experimental studies suggest that immune cells and other …

As a highly promising nanomaterial, exploring the impact of the liver, a vital organ, stands
out as a crucial focus in the examination of its biological effects. Kupffer cells (KCs) are one …

In recent decades, the global prevalence of metabolic syndrome has surged, posing a
significant public health challenge. Metabolic disorders, encompassing diabetes, obesity …

Introduction Non-alcoholic steatohepatitis (NASH), an advanced subtype of non-alcoholic
fatty liver disease (NAFLD), has becoming the most important aetiology for end-stage liver …