The excessive accumulation of extracellular matrix proteins results in fibrosis—a condition
implicated in several diseased conditions, such as nonalcoholic steatohepatitis, viral …

Purpose Fibrosis is the only histological feature reflecting the severity and prognosis of
nonalcoholic steatohepatitis (NASH). We aim to explore novel genes associated with fibrosis …

The human liver is a complex organ made up of multiple specialized cell types that carry out
key physiological functions. An incomplete understanding of liver biology limits our ability to …

Background & Aims Primary sclerosing cholangitis (PSC) is a progressive cholangiopathy
characterised by fibrotic stricturing and inflammation of bile ducts, which seems to be driven …

Steatotic liver diseases (SLD) are the principal worldwide cause of cirrhosis and end-stage
liver cancer, affecting nearly a quarter of the global population. SLD includes metabolic …

Myeloid-specific ablation of Basp1 ameliorates diet-induced... : Hepatology Myeloid-specific
ablation of Basp1 ameliorates diet-induced NASH in mice by attenuating pro-inflammatory …

Dendritic cells (DCs) are major antigen-presenting cells that connect innate and adaptive
immunity. Hepatic DCs are less activated and contribute to maintain the tolerogenic …

Besides their well-known role in initiating adaptive immune responses, several groups have
studied the role of dendritic cells (DCs) in the context of chronic metabolic inflammation …

Nonalcoholic steatohepatitis (NASH) is a progressive fibrotic disease associated with an
increased risk of developing hepatocellular carcinoma; at present, no efficient therapeutic …

Hepatocytes comprise the majority of the liver and largely exert metabolic functions,
whereas non-parenchymal cells (NPCs)—comprising Kupffer cells, dendritic cells and liver …