The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …

Context: Central precocious puberty (CPP) results from premature activation of the
hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with …

Background Delta-like homolog 1 (DLK1), also called preadipocyte factor 1, prevents
adipocyte differentiation and has been considered a molecular gatekeeper of adipogenesis …

MKRN3 mutations represent the most common genetic cause of central precocious puberty
(CPP) but associations between genotype and clinical features have not been extensively …

This review presents a comprehensive discussion of the clinical condition of delayed
puberty, a common presentation to the pediatric endocrinologist, which may present both …

Precocious puberty is defined as the appearance of secondary sex characteristics before 8
years of age in girls and before 9 years of age in boys. Central precocious puberty (CPP) is …

Pubertal timing varies considerably and is associated with later health outcomes. We
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …

Context Loss-of-function mutations of makorin RING finger protein 3 (MKRN3) are the most
common monogenic cause of familial central precocious puberty (CPP). Objective To …