[HTML][HTML] A systematic review of computational approaches to understand cancer biology for informed drug repurposing

F Ahmed, A Samantasinghar, AM Soomro, S Kim… - Journal of Biomedical …, 2023 - Elsevier
Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …

Informatics on Drug Repurposing for Breast Cancer

H Zhou, H Liu, Y Yu, X Yuan, L Xiao - Drug Design, Development …, 2023 - Taylor & Francis
Moving a new drug from bench to bedside is a long and arduous process. The tactic of drug
repurposing, which solves “new” diseases with “old” existing drugs, is more efficient and …

Network-based drug repurposing identifies small molecule drugs as immune checkpoint inhibitors for endometrial cancer

F Ahmed, A Samantasinghar, W Ali, KH Choi - Molecular Diversity, 2024 - Springer
Endometrial cancer (EC) is the 6th most common cancer in women around the world. Alone
in the United States (US), 66,200 new cases and 13,030 deaths are expected to occur in …

[HTML][HTML] Using artificial intelligence for drug discovery: A bibliometric study and future research agenda

E Karger, M Kureljusic - Pharmaceuticals, 2022 - mdpi.com
Drug discovery is usually a rule-based process that is carefully carried out by pharmacists.
However, a new trend is emerging in research and practice where artificial intelligence is …

[HTML][HTML] Drug–disease association prediction with literature based multi-feature fusion

H Kang, L Hou, Y Gu, X Lu, J Li, Q Li - Frontiers in Pharmacology, 2023 - frontiersin.org
Introduction: Exploring the potential efficacy of a drug is a valid approach for drug
development with shorter development times and lower costs. Recently, several …

[HTML][HTML] A transcriptome-and interactome-based analysis identifies repurposable drugs for human breast cancer subtypes

F Conte, P Sibilio, G Fiscon, P Paci - Symmetry, 2022 - mdpi.com
Breast cancer (BC) is a heterogeneous and complex disease characterized by different
subtypes with distinct morphologies and clinical implications and for which new and effective …

Repurposing therapy of ibrexafungerp vulvovaginal candidiasis drugs as cancer therapeutics

T Rustandi, AM Yumassik, FS Ilahi, R Alfian… - Frontiers in …, 2024 - frontiersin.org
The prevalence of cancer in 2022, according to World Health Organization (WHO) data, is
20 million new cases and 9.7 deaths. The comparison of death rates based on gender is that …

[HTML][HTML] A network-based drug prioritization and combination analysis for the MEK5/ERK5 pathway in breast cancer

R Odongo, A Demiroglu-Zergeroglu, T Çakır - BioData Mining, 2024 - Springer
Background Prioritizing candidate drugs based on genome-wide expression data is an
emerging approach in systems pharmacology due to its holistic perspective for preclinical …

NMSDR: Drug repurposing approach based on transcriptome data and network module similarity

Ü Ünsal, A Cüvitoğlu, K Turhan, Z Işık - Molecular Informatics, 2023 - Wiley Online Library
Computational drug repurposing aims to discover new treatment regimens by analyzing
approved drugs on the market. This study proposes previously approved compounds that …

Tool and Techniques on Computer-Aided Drug Design for Targeted Cancer Therapy

VG Niveditha, V Sindhu, MPJ Kizhakedathil… - … Cancer Therapy in …, 2023 - Springer
Cancer is a highly debilitating disease affecting millions around the world. The current drugs
marketed are incapable of eradicating the same. Hence, there is a dire need to find a new …