Recent findings suggest that the cellular and extracellular materials surrounding the
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …

Highlights•Metal nanoparticles have been extensively explored for the management of
various disease conditions including cancer.•Metal nanoparticles showed inherent …

Introduction: Calcium carbonate (CaCO3) has broad biomedical utilizations owing to its
availability, low cost, safety, biocompatibility, pH-sensitivity and slow biodegradability …

Because free therapeutic drug molecules often have adverse effects on normal tissues,
deliver scanty drug concentrations and exhibit a potentially low efficacy at pathological sites …

Porous inorganic nanostructured materials are widely used nowadays as drug delivery
carriers due to their adventurous features: suitable architecture, large surface area and …

Calcium carbonate nanoparticles have been widely used in biomedicine due to their
biocompatibility and biodegradability. Recently, calcium carbonate nanoparticles are largely …

The drug nanocrystals (NCs) with unique physicochemical properties are now considered
as a promising drug delivery system for poorly water-soluble drugs. So far> 20 formulations …

Nanocrystals are pure drug crystals with sizes in the nanometer range. Due to the
advantages of high drug loading, platform stability, and ease of scaling-up, nanocrystals …

Introduction In recent years, the applications of calcium carbonate (CaCO3) nanoparticles
(NPs) have gained extensive interest as targeted drug/gene delivery systems to cancerous …

Doxorubicin (DOX) is the most effective chemotherapeutic drug developed against broad
range of cancers such as solid tumours, transplantable leukemias and lymphomas …