Childhood nephrotic syndromes are most commonly caused by one of two idiopathic
diseases: minimal-change nephrotic syndrome (MCNS) and focal segmental …

Hereditary Proteinuria Syndromes and Mechanisms of Proteinuria | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

We investigated the value of genetic, histopathologic, and early treatment response
information in prognosing long-term renal outcome in children with primary steroid-resistant …

Nephrotic syndrome (NS) represents the association of proteinuria, hypoalbuminemia,
edema, and hyperlipidemia. Steroid-resistant NS (SRNS) is defined by primary resistance to …

NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic
syndrome and low post-transplant recurrence. Background Mutations of NPHS2 are …

Hereditary nephrotic syndrome is a heterogeneous disease, characterized by heavy
proteinuria and renal failure. Mutations of NPHS1 or NPHS2, the genes encoding for …

Background: Steroid resistant nephrotic syndrome (SRNS) is a rare condition, accounting for
10–15% of all children with idiopathic nephrotic syndrome. SRNS can be caused by genetic …

Podocytes are specialized epithelial cells covering the basement membrane of the
glomerulus in the kidney. The molecular mechanisms underlying the role of podocytes in …

Mutations in NPHS2, encoding podocin, have been identified in childhood onset focal and
segmental glomerulosclerosis (FSGS). The role of NPHS2 in adult disease is less well …

Background The aim of this study was to elucidate whether genetic screening test results of
pediatric patients with steroid-resistant nephrotic syndrome (SRNS) vary with ethnicity …