[HTML][HTML] Molecular targets of natural compounds with anti-cancer properties

M Kubczak, A Szustka, M Rogalińska - International Journal of Molecular …, 2021 - mdpi.com
Cancer is the second leading cause of death in humans. Despite rapid developments in
diagnostic methods and therapies, metastasis and resistance to administrated drugs are the …

[HTML][HTML] Epigenetics of cognition and behavior: insights from Mendelian disorders of epigenetic machinery

R Ng, A Kalinousky, J Harris - Journal of Neurodevelopmental Disorders, 2023 - Springer
Epigenetics, one mechanism by which gene expression can change without any changes to
the DNA sequence, was described nearly a century ago. However, the importance of …

[HTML][HTML] Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment

S Kowalski, J Karska, M Tota, K Skinderowicz… - Molecules, 2024 - mdpi.com
The elevated occurrence of non-melanoma skin cancer (NMSC) and the adverse effects
associated with available treatments adversely impact the quality of life in multiple …

[HTML][HTML] “Bet hedging” against climate change in developing and adult animals: roles for stochastic gene expression, phenotypic plasticity, epigenetic inheritance and …

WW Burggren, JF Mendez-Sanchez - Frontiers in Physiology, 2023 - frontiersin.org
Animals from embryos to adults experiencing stress from climate change have numerous
mechanisms available for enhancing their long-term survival. In this review we consider …

Fucoxanthin elicits epigenetic modifications, Nrf2 activation and blocking transformation in mouse skin JB6 P+ cells

Y Yang, I Yang, M Cao, Z Su, R Wu, Y Guo, M Fang… - The AAPS journal, 2018 - Springer
Nuclear factor erythroid-2-related factor-2 (Nrf2 or NFE2L2) is a master regulator of the anti-
oxidative stress response, which is involved in the defense against many oxidative …

Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds

C Vidoni, A Ferraresi, E Secomandi, L Vallino… - Seminars in cancer …, 2020 - Elsevier
Despite the undeniable progress made in the last decades, cancer continues to challenge
the scientists engaged in searching for an effective treatment for its prevention and cure …

Epigenetics of skin cancer: Interventions by selected bioactive phytochemicals

D Penta, BS Somashekar… - Photodermatology …, 2018 - Wiley Online Library
The prevalence and risk of skin cancer have been increasing over past three decades. Two
major types of skin cancer observed in humans are melanoma and nonmelanoma …

[HTML][HTML] Targeting the epigenome in in-stent restenosis: from mechanisms to therapy

X Yang, Y Yang, J Guo, Y Meng, M Li, P Yang… - … Therapy-Nucleic Acids, 2021 - cell.com
Coronary artery disease (CAD) is one of the most common causes of death worldwide. The
introduction of percutaneous revascularization has revolutionized the therapy of patients …

[HTML][HTML] BRD9 inhibition by natural polyphenols targets DNA damage/repair and apoptosis in human colon cancer cells

S Kapoor, E Damiani, S Wang, R Dharmanand… - Nutrients, 2022 - mdpi.com
Epigenetic mechanisms play an important role in the etiology of colorectal cancer (CRC)
and other malignancies due, in part, to deregulated bromodomain (BRD) functions …

[HTML][HTML] Marine-derived secondary metabolites as promising epigenetic bio-compounds for anticancer therapy

M Conte, E Fontana, A Nebbioso, L Altucci - Marine drugs, 2020 - mdpi.com
Sessile organisms such as seaweeds, corals, and sponges continuously adapt to both
abiotic and biotic components of the ecosystem. This extremely complex and dynamic …