A review of disintegration mechanisms and measurement techniques

D Markl, JA Zeitler - Pharmaceutical research, 2017 - Springer
Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to
administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically …

Characterisation of pore structures of pharmaceutical tablets: A review

D Markl, A Strobel, R Schlossnikl, J Bøtker… - International journal of …, 2018 - Elsevier
Traditionally, the development of a new solid dosage form is formulation-driven and less
focus is put on the design of a specific microstructure for the drug delivery system. However …

Pharmaceutical applications of magnetic resonance imaging (MRI)

JC Richardson, RW Bowtell, K Mäder… - Advanced drug delivery …, 2005 - Elsevier
Magnetic resonance imaging (MRI) is a powerful imaging modality that provides internal
images of materials and living organisms on a microscopic and macroscopic scale. It is non …

In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms

JA Zeitler, LF Gladden - European Journal of Pharmaceutics and …, 2009 - Elsevier
Tomographic imaging techniques offer new prospects for a better understanding of the
quality, performance and release mechanisms of pharmaceutical solid dosage forms. It is …

Tablet disintegration studied by high-resolution real-time magnetic resonance imaging

J Quodbach, A Moussavi, R Tammer, J Frahm… - Journal of …, 2014 - Elsevier
The present work employs recent advances in high-resolution real-time magnetic resonance
imaging (MRI) to investigate the disintegration process of tablets containing disintegrants. A …

Characterization of pharmaceutical tablets by X-ray tomography

J Vijayakumar, NM Goudarzi, G Eeckhaut… - Pharmaceuticals, 2023 - mdpi.com
Solid dosage forms such as tablets are extensively used in drug administration for their
simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is …

Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration

M Al-Sharabi, D Markl, T Mudley, P Bawuah… - International Journal of …, 2020 - Elsevier
Fast disintegrating tablets have commonly been used for fast oral drug delivery to patients
with swallowing difficulties. The different characteristics of the pore structure of such …

MRI of mass transport in porous media: Drying and sorption processes

IV Koptyug - Progress in Nuclear Magnetic Resonance …, 2012 - Elsevier
A title seldom gives exhaustive information about the content it precedes. Consequently, we
sometimes find ourselves disappointed when we realize that a paper is not about what we …

[HTML][HTML] Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging

D Markl, P Wang, C Ridgway, AP Karttunen… - … Research and Design, 2018 - Elsevier
Cost effectiveness, ease of use and patient compliance make pharmaceutical tablets the
most popular and widespread form to administer a drug to a patient. Tablets typically consist …

Application of UV dissolution imaging to pharmaceutical systems

B Brown, A Ward, Z Fazili, J Østergaard… - Advanced Drug Delivery …, 2021 - Elsevier
UV–vis spectrometry is widely used in the pharmaceutical sciences for compound
quantification, alone or in conjunction with separation techniques, due to most drug entities …