[PDF][PDF] Course and outcome of hepatitis C

JH Hoofnagle - Hepatology, 2002 - Wiley Online Library
The hepatitis C virus (HCV) is a small enveloped RNA virus belonging to the family
flaviviridae and genus hepacivirus. The HCV RNA genome is 9,600 nucleotides in length …

Pathogenesis, diagnosis and management of hepatitis C

N Boyer, P Marcellin - Journal of hepatology, 2000 - Elsevier
The hepatitis C virus (HCV) is the leading cause of chronic liver disease worldwide. It is
estimated that about 170 million people are chronically infected with HCV. Chronic hepatitis …

Hepatitis C virus envelope glycoprotein E2 glycans modulate entry, CD81 binding, and neutralization

E Falkowska, F Kajumo, E Garcia, J Reinus… - Journal of …, 2007 - Am Soc Microbiol
Hepatitis C virus (HCV) is a major human pathogen that causes serious liver disease,
including cirrhosis and hepatocellular carcinoma. The primary target cells of HCV are …

Recent advances in the molecular biology of hepatitis C virus

S Rosenberg - Journal of molecular biology, 2001 - Elsevier
The Hepatitis C virus is a positive-stranded RNA virus which is the causal agent for a chronic
liver infection afflicting more than 170,000,000 people world-wide. The HCV genome is …

[HTML][HTML] Chinese expert consensus on cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignancies

Y Li, YF Zhou, H Liang, HQ Wang, JH Hao… - World journal of …, 2016 - ncbi.nlm.nih.gov
Locoregional spread of abdominopelvic malignant tumors frequently results in peritoneal
carcinomatosis (PC). The prognosis of PC patients treated by conventional systemic …

3D QSAR and molecular docking studies of benzimidazole derivatives as hepatitis C virus NS5B polymerase inhibitors

PD Patel, MR Patel, N Kaushik-Basu… - Journal of chemical …, 2008 - ACS Publications
The urgent need for novel HCV antiviral agents has provided an impetus for understanding
the structural requisites of NS5B polymerase inhibitors at the molecular level. Toward this …

Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase

TT Talele, P Arora, SS Kulkarni, MR Patel… - Bioorganic & medicinal …, 2010 - Elsevier
Hepatitis C virus (HCV) NS5B polymerase is a key target for the development of therapeutic
agents aimed at the treatment of HCV infections. Here we report on the identification of novel …

Follow-up studies of treatment for hepatitis C virus infection among injection drug users

O Dalgard - Clinical Infectious Diseases, 2005 - academic.oup.com
Physicians are reluctant to treat chronic hepatitis C virus (HCV) infection in active injection
drug users (IDUs). An important reason for this is concern about reinfection after successful …

Nonhuman primates: a critical role in current disease research

LR Sibal, KJ Samson - ILAR journal, 2001 - academic.oup.com
This review article emphasizes the critical role of nonhuman primates (NHPs) in biomedical
research. It focuses on the most recent contributions that NHPs have made to the …

The challenge of developing a vaccine against hepatitis C virus

X Forns, J Bukh, RH Purcell - Journal of hepatology, 2002 - Elsevier
Hepatitis C virus (HCV) is a single stranded positivesense RNA virus belonging to the
Flaviviridae family [1]. Members of this family are small enveloped viruses that have been …