Abstract FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is
involved in tumor suppression and planar cell polarity (PCP). FAT1 and FAT4 undergo the …

Wnt/β-catenin pathway activation caused by adenomatous polyposis coli (APC) mutations
occurs in approximately 80% of sporadic colorectal cancers (CRC). The antihelminth …

Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. It is also the
third most common cancer diagnosis among men, and the second most common cancer …

Ginsenosides are a class of active components extracted from ginseng plants (such as
Panax ginseng, Panax quinquefolium, and Panax notoginseng). Ginsenosides have …

Obesity is associated mainly with adipose cell enlargement in adult man (hypertrophic
obesity), whereas the formation of new fat cells (hyperplastic obesity) predominates in the …

Aging is a cellular state characterized by a permanent cessation of cell division and evasion
of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial …

Limited information is available regarding epigenomic events mediating initiation and
progression of tobacco-induced lung cancers. In this study, we established an in vitro system …

Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the
WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell …

Colorectal cancer (CRC) is the third most common form of cancer and the second cause of
cancer-related death in the Western world, leading to 655,000 deaths worldwide per year …

G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …