Appropriate treatment of head and neck squamous cell cancer (HNSCC) remains one of the
most difficult challenges in head and neck oncology. Overall survival of patients with …

Currently, antibiotics are the most common treatment for bacterial infections in clinical
practice. However, with the abuse of antibiotics and the emergence of drug-resistant …

Spatiotemporal control of Wnt signaling is essential for the development and homeostasis of
many tissues. The transmembrane E3 ubiquitin ligases ZNRF3 (zinc and ring finger 3) and …

Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions
mainly in homeostasis and immune response. HSCs transplantation has been applied for …

WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of
the secreted extracellular matrix–associated proteins of the CCN family and a target gene of …

While immune checkpoint blockade is associated with prolonged responses in multiple
cancers, most patients still do not benefit from this therapeutic strategy. The Wnt-β-catenin …

Therapies of cancer are as diverse as multifaceted the cancer is. Anticancer drugs include,
but not limited to synthetic, semisynthetic and natural drugs and monoclonal antibodies. A …

The majority of women diagnosed with epithelial ovarian cancer eventually develop
recurrence, which rapidly evolves into chemoresistant disease. Persistence of ovarian …

WNT family members are secreted-type glycoproteins to orchestrate embryogenesis, to
maintain homeostasis, and to induce pathological conditions. FZD1, FZD2, FZD3, FZD4 …

WNT5A is a cancer-associated gene involved in invasion and metastasis of melanoma,
breast cancer, pancreatic cancer, and gastric cancer. WNT5A transduces signals through …