[HTML][HTML] Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the
triplication of the critical region of human chromosome 21 (HSA21). Major studies were …
triplication of the critical region of human chromosome 21 (HSA21). Major studies were …
Exploring the Conformational and Binding Dynamics of HMGA2· DNA Complexes Using Trapped Ion Mobility Spectrometry–Mass Spectrometry
K Jeanne Dit Fouque, SN Sipe… - Journal of the …, 2022 - ACS Publications
The mammalian high mobility group protein AT-hook 2 (HMGA2) is an intrinsically
disordered DNA-binding protein expressed during embryogenesis. In the present work, the …
disordered DNA-binding protein expressed during embryogenesis. In the present work, the …
Exploring the Conformations and Binding Location of HMGA2· DNA Complexes Using Ion Mobility Spectrometry and 193 nm Ultraviolet Photodissociation Mass …
SN Sipe, K Jeanne Dit Fouque… - Journal of the …, 2022 - ACS Publications
Although it is widely accepted that protein function is largely dependent on its structure,
intrinsically disordered proteins (IDPs) lack defined structure but are essential in proper …
intrinsically disordered proteins (IDPs) lack defined structure but are essential in proper …
Identification and validation of chromatin regulator-related signatures as a novel prognostic model for low-grade gliomas using translational bioinformatics
B Wang, Y Feng, Z Li, F Zhou, J Luo, B Yang, S Long… - Life Sciences, 2024 - Elsevier
Aims The purpose of this study is to explore the potential biological role and prognostic
significance of chromatin regulators (CRs) in low-grade gliomas (LGGs). Main methods CRs …
significance of chromatin regulators (CRs) in low-grade gliomas (LGGs). Main methods CRs …
Proteomic analysis identifies HMGA2 as a novel biomarker of overall survival in papillary renal cell carcinoma
T Wei, H Xu, H Liang, Y Lian, H Chen, Z Zheng… - Cancer …, 2023 - Wiley Online Library
Purpose Although papillary renal cell carcinoma (PRCC) has a relatively favorable
prognosis, a small number of patients with lymph node or distant metastasis have a poor …
prognosis, a small number of patients with lymph node or distant metastasis have a poor …
[HTML][HTML] Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis
C Cheng, H Yao, H Li, J Liu, Z Liu, Y Wu, L Zhu… - … Pharmaceutica Sinica B, 2024 - Elsevier
HMGA2, a pivotal transcription factor, functions as a versatile regulator implicated in the
progression of diverse aggressive malignancies. In this study, mass spectrometry was …
progression of diverse aggressive malignancies. In this study, mass spectrometry was …