The functional neural circuits are partially repaired after an ischemic stroke in the central
nervous system (CNS). In the CNS, neurovascular units, including neurons, endothelial …

Gaseous molecules have been increasingly explored for therapeutic development. Here,
following an analytical background introduction, a systematic review of medical gas …

Heme oxygenase (HO) has both beneficial and detrimental effects via its metabolites,
including carbon monoxide (CO), biliverdin or bilirubin, and ferrous iron. HO-1 is an …

The pathogenesis of Alzheimer's disease (AD) remains to be elucidated. Oxidative damage
and excessive beta-amyloid oligomers are components of disease progression but it is …

Carbon monoxide (CO) is not only known as a toxic gas due to its characteristics as an
odorless molecule and its rapid binding to haem-containing molecules, thus inhibiting the …

Mitochondrial damage plays a prominent role in glaucoma. The only way cells can degrade
whole mitochondria is via autophagy, in a process called mitophagy. Thus, studying …

Regeneration of adult neural circuits after an injury is limited in the central nervous system
(CNS). Heme oxygenase (HO) is an enzyme that produces HO metabolites, such as carbon …

Macular edema and its further complications due to the leakage from the choroidal
neovascularization in course of the age-related macular degeneration (AMD) is a leading …

Astrocytes play a key role by providing antioxidant support to nearby neurons under
oxidative stress. We have previously demonstrated that in vitro astroglial subtype 3 …

This chapter addresses the current state of the field with regard to potential mechanisms by
which CO modulates cell survival, inflammation, proliferation, and metabolism. The major …