Gangliosides, a heterogeneous family of glycosphingolipids abundant in the brain, have
been shown to affect neuronal plasticity during development, adulthood and aging. This …

Delayed or secondary neuronal damage following traumatic injury to the central nervous
system (CNS) may result from pathologic changes in the brain's endogenous neurochemical …

The widespread use of insulin and oral hypoglycaemic agents has increased the incidence
of hypoglycaemic brain damage due to accidental, suicidal, or homicidal overdose …

Gangliosides have been shown to be necessary for β-amyloid (Aβ) binding and
aggregation. GD3 synthase (GD3S) is responsible for biosynthesis of the b-and c-series …

Glutamate, the major central nervous system neurotransmitter, may have potent neurotoxic
activity under conditions of metabolic stress. By receptor autoradiography, we have …

Excitatory amino acid-mediated neurotoxicity was investigated in motoneuron-enriched
cultures from fetal rats at 12–14 days of gestation. The cultures were mainly composed of …

J. Neurochem.(2008) 104, 1466–1477. Abstract The ganglioside GM1 promotes neuronal
growth, differentiation, survival, phenotypic expression, and function restoration, by …

In a randomized double-blind cross-over study, humans with chronic spinal cord injury
received ganglioside GM-1 or placebo for 2 months. GM-1, administered intravenously at a …

Neurons cultured from rodent central nervous system tissues represent important tools in the
study of neurodegenerative disease mechanisms and neuroregenerative processes …

Chemokine receptors, in particular, CXCR4 and CCR5, mediate human immunodeficiency
virus type 1 (HIV‐1) infection of immunocompetent cells and the apoptosis of these cells …