Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

H Zhu, D Bi, Y Zhang, C Kong, J Du, X Wu… - Signal transduction and …, 2022 - nature.com
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

[HTML][HTML] Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions

MV Fogaça, RS Duman - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …

GABAA receptors: structure, function, pharmacology, and related disorders

A Ghit, D Assal, AS Al-Shami, DEE Hussein - Journal of Genetic …, 2021 - Springer
Background γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …

Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

Major depression: one brain, one disease, one set of intertwined processes

EV Filatova, MI Shadrina, PA Slominsky - Cells, 2021 - mdpi.com
Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …

Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder

JT Kantrowitz, Z Dong, MS Milak, R Rashid… - Translational …, 2021 - nature.com
Glutamate (Glu) and gamma-aminobutyric acid (GABA) are implicated in the
pathophysiology of major depressive disorder (MDD). GABA levels or GABAergic …

[HTML][HTML] Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs

E Dale, B Bang-Andersen, C Sánchez - Biochemical pharmacology, 2015 - Elsevier
The monoamine hypothesis has been the prevailing hypothesis of depression over the last
several decades. It states that depression is associated with reduced monoamine function …

Role of the intestinal microbiome, intestinal barrier and psychobiotics in depression

P Trzeciak, M Herbet - Nutrients, 2021 - mdpi.com
The intestinal microbiota plays an important role in the pathophysiology of depression. As
determined, the microbiota influences the shaping and modulation of the functioning of the …

Brexanolone, a GABAA Modulator, in the Treatment of Postpartum Depression in Adults: A Comprehensive Review

AN Edinoff, AS Odisho, K Lewis, A Kaskas… - Frontiers in …, 2021 - frontiersin.org
Postpartum depression (PPD) is one of the three major categories on the spectrum of
postpartum psychiatric syndromes. Postpartum psychiatric syndromes are classified as …

Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study

JX Pan, JJ Xia, FL Deng, WW Liang, J Wu… - Translational …, 2018 - nature.com
Major depressive disorder (MDD) is a debilitating psychiatric illness. However, there is
currently no objective laboratory-based diagnostic tests for this disorder. Although …