Neural mechanisms underlying the coughing reflex
H Lu, P Cao - Neuroscience Bulletin, 2023 - Springer
Breathing is an intrinsic natural behavior and physiological process that maintains life. The
rhythmic exchange of gases regulates the delicate balance of chemical constituents within …
rhythmic exchange of gases regulates the delicate balance of chemical constituents within …
A succinate/SUCNR1-brush cell defense program in the tracheal epithelium
Host-derived succinate accumulates in the airways during bacterial infection. Here, we show
that luminal succinate activates murine tracheal brush (tuft) cells through a signaling …
that luminal succinate activates murine tracheal brush (tuft) cells through a signaling …
Neuroendocrine cells initiate protective upper airway reflexes
LF Seeholzer, D Julius - Science, 2024 - science.org
Airway neuroendocrine (NE) cells have been proposed to serve as specialized sensory
epithelial cells that modulate respiratory behavior by communicating with nearby nerve …
epithelial cells that modulate respiratory behavior by communicating with nearby nerve …
Investigating pulmonary neuroendocrine cells in human respiratory diseases with airway models
N Candeli, T Dayton - Disease Models & Mechanisms, 2024 - journals.biologists.com
Despite accounting for only∼ 0.5% of the lung epithelium, pulmonary neuroendocrine cells
(PNECs) appear to play an outsized role in respiratory health and disease. Increased PNEC …
(PNECs) appear to play an outsized role in respiratory health and disease. Increased PNEC …
Dynamic measurement of airway surface liquid volume with an ex vivo trachea-chip
The volume and composition of airway surface liquid (ASL) is regulated by liquid secretion
and absorption across airway epithelia, controlling the pH, solute concentration, and …
and absorption across airway epithelia, controlling the pH, solute concentration, and …
Pulmonary succinate receptor 1 elevation in high-fat diet mice exacerbates lipopolysaccharides-induced acute lung injury via sensing succinate
L Liu, W Tang, S Wu, J Ma, K Wei - … Acta (BBA)-Molecular Basis of Disease, 2024 - Elsevier
Background Individuals with obesity have higher level of circulating succinate, which acts as
a signaling factor that initiates inflammation. It is obscure whether succinate and succinate …
a signaling factor that initiates inflammation. It is obscure whether succinate and succinate …
Sentinels of the airways
Z Zhu, X Sun - Science, 2024 - science.org
The respiratory tract is essential for breathing but is also important for detecting and
responding to inhaled harmful (noxious) stimuli, such as pollutants, pathogens, water, and …
responding to inhaled harmful (noxious) stimuli, such as pollutants, pathogens, water, and …
A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium
The human airway contains specialized rare epithelial cells whose roles in respiratory
disease are not well understood. Ionocytes express the Cystic Fibrosis Transmembrane …
disease are not well understood. Ionocytes express the Cystic Fibrosis Transmembrane …
Airway succinate chemosensing induces CFTR-dependent anion secretion and mucus clearance which is impaired in cystic fibrosis.
T Apablaza, M Barros-Poblete, L Delpiano… - bioRxiv, 2024 - biorxiv.org
The respiratory tract possesses a highly regulated innate defense system which includes
efficient cilia-mediated mucus transport or mucociliary clearance (MCC). This essential …
efficient cilia-mediated mucus transport or mucociliary clearance (MCC). This essential …
Solitary chemosensory cells in the respiratory tract of man
D Hamarsheh - 2023 - jlupub.ub.uni-giessen.de
Objective: Specialized sensory epithelial cells sensing noxious chemicals and initiating
protective reflexes are found along the mammalian respiratory tract. Studies in mice …
protective reflexes are found along the mammalian respiratory tract. Studies in mice …