Des défauts de réplication de l'ADN, autrement connus sous le terme de stress réplicatif,
sont une source d'instabilité génétique qui peuvent conduire à l'entrée en mitose de cellules …

Upon DNA damage, cells promptly activate the cellular DNA damage response (DDR), a
surveillance mechanism that leads to DNA repair, cell cycle arrest, and apoptosis. DDR …

This report summarizes an international conference on molecular machines convened at
New York University, Abu Dhabi by Piergiorgio Percipalle, George Shubeita and Serdal …

An RNA: DNA hybrid refers to the base pairing of RNA and DNA. In particular, R-loops are
three-stranded nucleic acid structures composed of an RNA: DNA hybrid and a displaced …

La información genética debe estar almacenada de manera segura en la molécula de ADN.
Sin embargo, el ADN está continuamente expuesto a daños que alteran su estructura y …

Homologous recombination (HR) enables cells to overcome the threat of DNA double strand
breaks (DSB), allowing for repair without the loss of genetic information. Central to the HR …

Methylation of histone 3 at lysine 4 via lysine methyltransferases KMT2CA-D results in a
relaxed chromatin state, leading to transcriptional activation. In non-small cell lung cancer …

Disorders of ovulation account for 40% of female infertility to which improper oocyte
maturation contributes significantly. During mammalian oogenesis, oocytes accumulate …

Telomeres are specialized nucleoprotein complexes that protect natural chromosomal
termini from degradation and prevent their detection as of DNA damage. Therefore …

For decades, it was believed that RNA was merely an intermediate step between DNA and
protein effectors. It is now appreciated that RNA is an extremely versatile molecule that …