Oxytocin, vasopressin, and social behavior: from neural circuits to clinical opportunities

N Rigney, GJ de Vries, A Petrulis, LJ Young - Endocrinology, 2022 - academic.oup.com
Oxytocin and vasopressin are peptide hormones secreted from the pituitary that are well
known for their peripheral endocrine effects on childbirth/nursing and blood pressure/urine …

Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior

KM Dumais, AH Veenema - Frontiers in neuroendocrinology, 2016 - Elsevier
The neuropeptides vasopressin (VP) and oxytocin (OT) and their receptors in the brain are
involved in the regulation of various social behaviors and have emerged as drug targets for …

Considering sex as a biological variable in basic and clinical studies: an endocrine society scientific statement

A Bhargava, AP Arnold, DA Bangasser… - Endocrine …, 2021 - academic.oup.com
Abstract In May 2014, the National Institutes of Health (NIH) stated its intent to “require
applicants to consider sex as a biological variable (SABV) in the design and analysis of NIH …

Measuring oxytocin and vasopressin: bioassays, immunoassays and random numbers

G Leng, N Sabatier - Journal of neuroendocrinology, 2016 - Wiley Online Library
In this review, we consider the ways in which vasopressin and oxytocin have been
measured since their first discovery. Two different ways of measuring oxytocin in widespread …

[HTML][HTML] Fatty acid oxidation is impaired in an orthologous mouse model of autosomal dominant polycystic kidney disease

LF Menezes, CC Lin, F Zhou, GG Germino - EBioMedicine, 2016 - thelancet.com
Background The major gene mutated in autosomal dominant polycystic kidney disease was
first identified over 20years ago, yet its function remains poorly understood. We have used a …

[HTML][HTML] GPCRs: The most promiscuous druggable receptor of the mankind

K Alhosaini, A Azhar, A Alonazi… - Saudi Pharmaceutical …, 2021 - Elsevier
All physiological events in living organisms originated as specific chemical/biochemical
signals on the cell surface and transmitted into the cytoplasm. This signal is translated within …

[HTML][HTML] Signal transduction in primary cilia–analyzing and manipulating GPCR and second messenger signaling

D Wachten, DU Mick - Pharmacology & therapeutics, 2021 - Elsevier
The primary cilium projects from the surface of most vertebrate cells, where it senses
extracellular signals to regulate diverse cellular processes during tissue development and …

[HTML][HTML] Diabetes insipidus: The other diabetes

S Kalra, AH Zargar, SM Jain, B Sethi… - Indian journal of …, 2016 - journals.lww.com
Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of
persons with the condition; disruption is due to increased thirst and passing of large volumes …

[HTML][HTML] Sex differences in the brain: a whole body perspective

GJ de Vries, NG Forger - Biology of sex differences, 2015 - Springer
Most writing on sexual differentiation of the mammalian brain (including our own) considers
just two organs: the gonads and the brain. This perspective, which leaves out all other body …

Urine osmolality, response to tolvaptan, and outcome in autosomal dominant polycystic kidney disease: results from the TEMPO 3: 4 trial

O Devuyst, AB Chapman, RT Gansevoort… - Journal of the …, 2017 - journals.lww.com
The vasopressin–cAMP–osmolality axis is abnormal in autosomal dominant polycystic
kidney disease (ADPKD). In the Tolvaptan Efficacy and Safety in Management of Autosomal …