Trends in GPCR drug discovery: new agents, targets and indications
G protein-coupled receptors (GPCRs) are the most intensively studied drug targets, mostly
due to their substantial involvement in human pathophysiology and their pharmacological …
due to their substantial involvement in human pathophysiology and their pharmacological …
Minimum information about an uncultivated virus genome (MIUViG)
We present an extension of the Minimum Information about any (x) Sequence (MIxS)
standard for reporting sequences of uncultivated virus genomes. Minimum Information about …
standard for reporting sequences of uncultivated virus genomes. Minimum Information about …
iPHoP: An integrated machine learning framework to maximize host prediction for metagenome-derived viruses of archaea and bacteria
The extraordinary diversity of viruses infecting bacteria and archaea is now primarily studied
through metagenomics. While metagenomes enable high-throughput exploration of the viral …
through metagenomics. While metagenomes enable high-throughput exploration of the viral …
Wildfire-dependent changes in soil microbiome diversity and function
Forest soil microbiomes have crucial roles in carbon storage, biogeochemical cycling and
rhizosphere processes. Wildfire season length, and the frequency and size of severe fires …
rhizosphere processes. Wildfire season length, and the frequency and size of severe fires …
VIBRANT: automated recovery, annotation and curation of microbial viruses, and evaluation of viral community function from genomic sequences
K Kieft, Z Zhou, K Anantharaman - Microbiome, 2020 - Springer
Background Viruses are central to microbial community structure in all environments. The
ability to generate large metagenomic assemblies of mixed microbial and viral sequences …
ability to generate large metagenomic assemblies of mixed microbial and viral sequences …
Likelihood ratios for out-of-distribution detection
Discriminative neural networks offer little or no performance guarantees when deployed on
data not generated by the same process as the training distribution. On such out-of …
data not generated by the same process as the training distribution. On such out-of …
Phage puppet masters of the marine microbial realm
Viruses numerically dominate our oceans; however, we have only just begun to document
the diversity, host range and infection dynamics of marine viruses, as well as the subsequent …
the diversity, host range and infection dynamics of marine viruses, as well as the subsequent …
VirFinder: a novel k-mer based tool for identifying viral sequences from assembled metagenomic data
Background Identifying viral sequences in mixed metagenomes containing both viral and
host contigs is a critical first step in analyzing the viral component of samples. Current tools …
host contigs is a critical first step in analyzing the viral component of samples. Current tools …
Identifying viruses from metagenomic data using deep learning
J Ren, K Song, C Deng, NA Ahlgren… - Quantitative …, 2020 - Wiley Online Library
Background The recent development of metagenomic sequencing makes it possible to
massively sequence microbial genomes including viral genomes without the need for …
massively sequence microbial genomes including viral genomes without the need for …
Understanding bacteriophage tail fiber interaction with host surface receptor: the key “blueprint” for reprogramming phage host range
Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …