Background: Recent studies show that intraoperative mechanical ventilation using low tidal
volumes (VT) can prevent postoperative pulmonary complications (PPCs). The aim of this …

Pulmonary atelectasis is common in the perioperative period. Physiologically, it is produced
when collapsing forces derived from positive pleural pressure and surface tension overcome …

Monocytes and macrophages are emerging as key players in mediating both the pathogen
response and sterile lung inflammation, including that arising from barotrauma and ischemia …

In patients with the acute respiratory distress syndrome (ARDS), lung imaging is a
fundamental tool in the study of the morphological and mechanistic features of the lungs …

This article is one of ten reviews selected from the Annual Update in Intensive Care and
Emergency Medicine 2018. Other selected articles can be found online at https://www …

Objective: Volutrauma and atelectrauma promote ventilator-induced lung injury, but their
relative contribution to inflammation in ventilator-induced lung injury is not well established …

Acute respiratory distress syndrome (ARDS) is a severe form of respiratory failure burden by
high hospital mortality. No specific pharmacologic treatment is currently available and its …

Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …

Mechanical ventilation is an essential method of patient support, but it may induce lung
damage, leading to ventilator-induced lung injury (VILI). VILI is the result of a complex …

AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing
hematopoietic stem cells from bone marrow to blood for transplantation in cancer. AMD3100 …