Granulocyte colony-stimulating factor plays a central role in the dynamic regulation of
neutrophil production and release from the bone marrow in response to environmental …

Evolutionary pressure has selected individuals with traits that allow them to survive to
reproduction, without consideration of the consequences for the post‐child rearing years …

Severe congenital neutropenia (SCN) is a genetically heterogeneous syndrome associated
with mutations of ELANE (ELA2), HAX1, GFI1, WAS, CSF3R or G6PC3. We investigated the …

Abstract Background The Severe Chronic Neutropenia International Registry (SCNIR) was
organized 10 years ago to improve understanding and treatment of the group of rare …

Our understanding of the pathogenesis of congenital and acquired neutropenia is rapidly
evolving. New ground-breaking observations have identified the genes responsible for …

The innate immune system represents the initial arm of host defense against pathogenic
bacteria, fungi, and parasites. Neutrophils, monocytes, and tissue-based macrophages are …

Neutrophil counts should be carefully evaluated in premature and critically ill neonates.
Although neutropenia is usually benign and runs a self-limited course in most neonates, it …

Natural killer (NK) cells are lymphocytes that are involved in controlling tumors or microbial
infections through the production of interferon gamma (IFN-γ). Granulocyte colony …

Granulocyte colony-stimulating factor (G-CSF) has had a major impact on the management
of “severe chronic neutropenia”(SCN), a collective term referring to congenital, idiopathic, or …

Gfi1 is central to several transcriptional circuits whose dysregulation leads to abnormal or
malignant hematopoiesis. These functional relationships are conserved from Drosophila …