Histone deacetylases (HDACs) are a superfamily of enzymes that catalyze the removal of
acetyl functional groups from lysine residues of histone and non-histone proteins. There are …

Cardiovascular disease remains the number one cause of death and disability worldwide
despite significant improvements in diagnosis, prevention, and early intervention efforts …

Aims Familial hypertrophic cardiomyopathy (HCM) is one the most common heart disorders,
with gene mutations in the cardiac sarcomere. Studying HCM with patient-specific induced …

Inhibition of class IIa histone deacetylase (HDAC) enzymes have been suggested as a
therapeutic strategy for a number of diseases, including Huntington's disease. Catalytic-site …

Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac
remodeling and hypertrophic gene expression; yet, the direct histone targets remain poorly …

Gliomas are the most common and aggressive malignancies of the central nervous system.
Histone deacetylases (HDACs) are important targets in cancer treatment. They regulate …

The epigenetic landscape and the responses to pharmacological epigenetic regulators in
each human are unique. Classes of epigenetic writers and erasers, such as histone …

Cardiovascular disease (CVD) represents a major challenge for health care systems, both in
terms of the high mortality associated with it and the huge economic burden of its treatment …

Mitochondria play a fundamental role in the maintenance of normal structure, function, and
survival of tissues. There is considerable evidence for mitochondrial dysfunction in …

The function of nuclear receptor corepressor 1 (NC oR1) in cardiomyocytes is unclear, and
its physiological and pathological implications are unknown. Here, we found that …