Critical functions of histone deacetylases (HDACs) in modulating inflammation associated with cardiovascular diseases

S Kulthinee, N Yano, S Zhuang, L Wang, TC Zhao - Pathophysiology, 2022 - mdpi.com
Histone deacetylases (HDACs) are a superfamily of enzymes that catalyze the removal of
acetyl functional groups from lysine residues of histone and non-histone proteins. There are …

Epigenetics and vascular diseases

MS Stratton, FM Farina, L Elia - Journal of molecular and cellular cardiology, 2019 - Elsevier
Cardiovascular disease remains the number one cause of death and disability worldwide
despite significant improvements in diagnosis, prevention, and early intervention efforts …

Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells

L Han, Y Li, J Tchao, AD Kaplan, B Lin… - Cardiovascular …, 2014 - academic.oup.com
Aims Familial hypertrophic cardiomyopathy (HCM) is one the most common heart disorders,
with gene mutations in the cardiac sarcomere. Studying HCM with patient-specific induced …

Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease

RW Bürli, CA Luckhurst, O Aziz… - Journal of medicinal …, 2013 - ACS Publications
Inhibition of class IIa histone deacetylase (HDAC) enzymes have been suggested as a
therapeutic strategy for a number of diseases, including Huntington's disease. Catalytic-site …

HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

JYY Ooi, NK Tuano, H Rafehi, XM Gao, M Ziemann… - Epigenetics, 2015 - Taylor & Francis
Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac
remodeling and hypertrophic gene expression; yet, the direct histone targets remain poorly …

[HTML][HTML] Comprehensive analysis of the differential expression and prognostic value of histone deacetylases in glioma

J Li, X Yan, C Liang, H Chen, M Liu, Z Wu… - Frontiers in cell and …, 2022 - frontiersin.org
Gliomas are the most common and aggressive malignancies of the central nervous system.
Histone deacetylases (HDACs) are important targets in cancer treatment. They regulate …

Human iPSC-cardiomyocytes as an experimental model to study epigenetic modifiers of electrophysiology

MR Pozo, GW Meredith, E Entcheva - Cells, 2022 - mdpi.com
The epigenetic landscape and the responses to pharmacological epigenetic regulators in
each human are unique. Classes of epigenetic writers and erasers, such as histone …

Histone deacetylase signaling in cardioprotection

LH Lehmann, BC Worst, DA Stanmore… - Cellular and Molecular Life …, 2014 - Springer
Cardiovascular disease (CVD) represents a major challenge for health care systems, both in
terms of the high mortality associated with it and the huge economic burden of its treatment …

Mitochondria and oxidative stress in the cardiorenal metabolic syndrome

AR Aroor, C Mandavia, J Ren, JR Sowers… - Cardiorenal …, 2012 - karger.com
Mitochondria play a fundamental role in the maintenance of normal structure, function, and
survival of tissues. There is considerable evidence for mitochondrial dysfunction in …

Nuclear receptor corepressor 1 represses cardiac hypertrophy

C Li, XN Sun, BY Chen, MR Zeng, LJ Du… - EMBO molecular …, 2019 - embopress.org
The function of nuclear receptor corepressor 1 (NC oR1) in cardiomyocytes is unclear, and
its physiological and pathological implications are unknown. Here, we found that …