To develop a cell-based assay to screen for human dopamine D1 receptor agonists or
antagonists from medicinal plant extracts, a stable Chinese hamster ovary (CHO) cell line …

The gross anatomical properties of the hippocampus and cerebellum structures are
preserved across mammalian species (Amaral and Lavenex 2007; Sillitoe et al. 2005). For …

Arguably, one of the main reasons for the pharmaceutical industry's current poor
performance in bringing successful new drugs to market is its over-reliance on animal data …

Previous studies have shown a reduction of dopaminergic D2 receptors (D2R) in the
striatum after hypoxia-ischemia in newborn rats. We show here an early and transient …

O ther chapters in this textbook address the questions of how psychotropic medications
affect the brain to reduce the severity of the clinical features and symptoms of psychiatric …

Molecular cloning of neurotransmitter receptors has enabled the application of in situ
hybridization histochemistry to the study of the regional distribution and cellular localization …

The five dopamine receptor subtypes (D1–D5) are members of the superfamily of G protein-
coupled receptors (see also Chapter 1). Dopamine receptors. have been known since 1978 …

The nonergot ligand pardoprunox (SLV308) is a dopamine (DA) D2/D3 and serotonin (5‐
HT) 1A receptor agonist and a new candidate for the treatment of Parkinson's disease. We …

Dopamine (DA) neurons and their associated receptors have long been known to be
implicated in the pathogenesis of Parkinson's disease (PD). The DA receptors …

In summary, we have illustrated and discussed the applicability of different techniques to the
study of neurotransmitter receptors in the human brain. Because of the availability of these …