Angiotensin IV (Ang IV) and des-Phe6Ang IV are naturally occurring neuroactive peptides of
the renin-angiotensin system (RAS) involved in memory processing. However, the relevant …

Before 1990, the multiplicity of dopamine receptors beyond D1 and D2 had remained a
controversial concept, despite its substantial clinical implications, at a time when it was …

The reinforcing properties of cocaine are likely exerted within the brain in the limbic
dopamine projections, particularly in the ventral striatum/nucleus accumbens (Kuhar et al …

The recently cloned dopamine D 3 receptor (DRD3) gene is of potential relevance to the
aetiology of bipolar disorder because of an almost exclusive expression in limbic tissue, the …

The expression of dopamine D3 receptors is relatively low in the adult brain and is mainly
restricted to the limbic region. We studied here the postnatal development of these receptors …

Binding characteristics of a novel radioiodinated ligand,[125 I] R (+) trans-7-hydroxy-2-(Nn-
propylN-3′-iodo-2′-propenyl) aminotetralin (125 I] R (+) trans-7-OH-PIPAT), were …

The in vivo effects of administration of the putative dopamine D 3 receptor agonist 7-hydroxy-
N, N-di-n-propylaminotetralin (7-OH-DPAT) were investigated in spontaneously …

D2 dopamine receptor (D2R) gene expression was analyzed by in situ hybridization and
D2R ligand autoradiography in the human striatum during ontogeny. D2R mRNA and ([3H] …

The selective functions of D3 receptors in the brain are still poorly understood, mainly
because all the ligands active at dopamine D3 receptors have also a high affinity for the D2 …

The therapeutic efficacy of current antipsychotic or antidepressant agents still present
important drawbacks such as delayed onset of action and a high percentage of non …