Background New drugs and new evidence concerning the use of established treatments
have become available since the publication of the first European League Against …

Gout is a picturesque presentation of uric acid disturbance. It is the most well understood
and described type of arthritis. Its epidemiology is studied. New insights into the …

Gout is the most common cause of inflammatory arthritis worldwide. In UK general practice,
the overall prevalence has increased from 1.4% in 1999 to 2.49% in 2012 [1], despite the …

Gout is the most common form of inflammatory arthritis and is a multifactorial disease
typically characterized by hyperuricemia and monosodium urate crystal deposition …

Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a
foundation of an excess body burden of uric acid, manifested in part by hyperuricemia …

Introduction: Urate-lowering therapy (ULT) is the cornerstone of gout management, which is
a widespread chronic illness characterized by hyperuricemia, arthropathy, tophus …

Purine metabolism in the circulatory system yields uric acid as its final oxidation product,
which is believed to be linked to the development of gout and kidney stones. Hyperuricemia …

We aimed to develop evidence-based multinational recommendations for the diagnosis and
management of gout. Using a formal voting process, a panel of 78 international …

Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

The central nervous system (CNS) is an active participant in the innate immune response to
infection and injury. In these studies, we show embryonic cortical neurons express a …