Healthy mitochondrial function is imperative for most tissues, but especially those with a high
energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular …

The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …

Rationale: Lipid overload-induced heart dysfunction is characterized by cardiomyocyte
death, myocardial remodeling, and compromised contractility, but the impact of excessive …

Extracellular vesicles are emerging key actors in adipocyte communication. Notably, small
extracellular vesicles shed by adipocytes stimulate fatty acid oxidation and migration in …

Fatty acid overload, either of the saturated palmitic acid (PA) or the unsaturated oleic acid
(OA), causes triglyceride accumulation into specialized organelles termed lipid droplets …

Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …

Bipolar disorder's core feature is the pathological disturbances in mood, often accompanied
by disrupted thinking and behavior. Its complex and heterogeneous etiology implies that a …

Mitochondrial health is critically dependent on the ability of mitochondria to undergo
changes in mitochondrial morphology, a process which is regulated by mitochondrial …

Clinically important links have been established between mitochondrial function and cardiac
physiology and disease in the context of signaling mechanisms, energy production, and …

The remodeling of the mitochondrial network is a critical process in maintaining cellular
homeostasis and is intimately related to mitochondrial function. The interplay between the …