Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines

P Cao, C Chen, A Liu, Q Shan, X Zhu, C Jia, X Peng… - Neuron, 2021 - cell.com
Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

Pathophysiology linking depression and type 2 diabetes: psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

R Subba, R Sandhir, SP Singh… - European Journal of …, 2021 - Wiley Online Library
Diabetes increases the likelihood of developing depression and vice versa. Research on
this bidirectional association has somewhat managed to delineate the interplay among …

Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis

Y Guo, JP Xie, K Deng, X Li, Y Yuan, Q Xuan… - Frontiers in Behavioral …, 2019 - frontiersin.org
Stress disturbs the balance of the gut microbiota and stimulates inflammation-to-brain
mechanisms. Moreover, stress leads to anxiety and depressive disorders. Bifidobacterium …

Once induced, it lasts for a long time: the structural and molecular signatures associated with depressive-like behavior after neonatal immune activation

JN Khantakova, NP Bondar, EV Antontseva… - Frontiers in Cellular …, 2022 - frontiersin.org
Adverse factors such as stress or inflammation in the neonatal period can affect the
development of certain brain structures and have negative delayed effects throughout the …

Ginsenoside‐Rg1 rescues stress‐induced depression‐like behaviors via suppression of oxidative stress and neural inflammation in rats

Y Li, L Wang, P Wang, C Fan, P Zhang… - Oxidative medicine …, 2020 - Wiley Online Library
Depression is an inflammatory‐related condition, with the progression in neuronal damage
resulting in major depression disorder. Ginsenoside‐Rg1, a sterol extract from the herb …

[HTML][HTML] Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation

SQ Dong, QP Zhang, JX Zhu, M Chen, CF Li… - Biomedicine & …, 2018 - Elsevier
Gypenosides, a saponins extract isolated from the Gynostemma pentaphyllum plant,
produces neuroprotective effects in the brain. Our previous studies have shown that …

Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro

J Song, W Zhang, J Wang, H Yang, X Zhao… - International …, 2018 - Elsevier
Neurodegenerative diseases are closely related to neuroinflammation. Drugs targeting
inflammation have been proved to be effective in many animal models. Salvianolic acid C …

Prior maternal separation stress alters the dendritic complexity of new hippocampal neurons and neuroinflammation in response to an inflammatory stressor in …

S Nicolas, AJ McGovern, CM Hueston… - Brain, Behavior, and …, 2022 - Elsevier
Stress during critical periods of neurodevelopment is associated with an increased risk of
developing stress-related psychiatric disorders, which are more common in women than …

Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice

X Wu, C Liu, L Chen, YF Du, M Hu, MN Reed… - International …, 2019 - Elsevier
Accumulating evidence has shown that tauroursodeoxycholic acid (TUDCA) is
neuroprotective in different animal models of neurological diseases. However, whether …

GR/NF-κB signaling pathway regulates hippocampal inflammatory responses in diabetic rats with chronic unpredictable mild stress

ZR Li, YS Han, Z Liu, HQ Zhao, J Liu, H Yang… - European journal of …, 2021 - Elsevier
Clinical studies have shown that diabetes can present with underlying depression, and a
combination of the two can lead to emotional, memory and cognitive disorders, closely …