The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

The function and regulation of different heterogeneous reactive states of astrocytes in
depression remain unclear. Here, we demonstrate that neurotoxic reactive (A1-like) …

According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …

With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …

Neurodegenerative diseases (NDDs) encompass a range of conditions that involve
progressive deterioration and dysfunction of the nervous system. Some of the common …

Protein S-nitros (yl) ation (SNO) is a posttranslational modification involved in diverse
processes in health and disease and can contribute to synaptic damage in Alzheimer's …

Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …

Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory
repute, is employed in traditional medicines in many countries. Rosemary contains carnosic …

Clearing amyloid-β (Aβ) through immunotherapy is one of the most promising therapeutic
approaches to Alzheimer's disease (AD). Although several monoclonal antibodies against …